Reaction Details |
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Target | Gamma-aminobutyric acid receptor subunit alpha-6 |
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Ligand | BDBM85683 |
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Substrate/Competitor | n/a |
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Ki | 2000±n/a nM |
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Comments | PDSP_555 |
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Citation | Vanover, KE; Rosenzweig-Lipson, S; Hawkinson, JE; Lan, NC; Belluzzi, JD; Stein, L; Barrett, JE; Wood, PL; Carter, RB Characterization of the anxiolytic properties of a novel neuroactive steroid, Co 2-6749 (GMA-839; WAY-141839; 3alpha, 21-dihydroxy-3beta-trifluoromethyl-19-nor-5beta-pregnan-20-one), a selective modulator of gamma-aminobutyric acid(A) receptors. J Pharmacol Exp Ther295:337-45 (2000) [PubMed] |
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More Info.: | Get all data from this article |
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Gamma-aminobutyric acid receptor subunit alpha-6 |
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Name: | Gamma-aminobutyric acid receptor subunit alpha-6 |
Synonyms: | GABA A Alpha6Beta3Gamma2 | GABA A receptor alpha-6/beta-2/gamma-2 | GABA receptor alpha-6 subunit | GBRA6_RAT | Gabra-6 | Gabra6 | Gamma-aminobutyric acid receptor subunit alpha-6 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 51188.24 |
Organism: | RAT |
Description: | GABA A Alpha6Beta2Gamma2 0 RAT::P30191 |
Residue: | 453 |
Sequence: | MLLLLPWLFSLLWIENAQAQLEDEGNFYSENVSRILDNLLEGYDNRLRPGFGGAVTEVKT
DIYVTSFGPVSDVEMEYTMDVFFRQTWTDERLKFKGPAEILSLNNLMVSKIWTPDTFFRN
GKKSIAHNMTTPNKLFRLMHNGTILYTMRLTINADCPMRLVNFPMDGHACPLKFGSYAYP
KSEIIYTWKKGPLYSVEVPEESSSLLQYDLIGQTVSSETIKSNTGEYVIMTVYFHLQRKM
GYFMIQIYTPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYA
TAMDWFIAVCFAFVFSALIEFAAVNYFTNLQSQKAERQAQTAAKPPVAKSKTTESLEAEI
VVHSDSKYHLKKRISSLTLPIVPSSEASKVLSRTPILPSTPVTPPLLLPAIGGTSKIDQY
SRILFPVAFAGFNLVYWIVYLSKDTMEVSSTVE
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BDBM85683 |
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n/a |
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Name | BDBM85683 |
Synonyms: | Co 2-6749 | Co-2-6749 | GMA-839 | WAY-141839 |
Type | Small organic molecule |
Emp. Form. | C21H31F3O3 |
Mol. Mass. | 388.4642 |
SMILES | C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](O)(CC[C@H]34)C(F)(F)F)[C@@H]1CC[C@@H]2C(=O)CO |
Structure |
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