Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetNischarin
LigandBDBM50016897
Substrate/Competitorn/a
Ki 31.6228±n/a nM
CommentsPDSP_544
Citation Millan, MJDekeyne, ANewman-Tancredi, ACussac, DAudinot, VMilligan, GDuqueyroix, DGirardon, SMullot, JBoutin, JANicolas, JPRenouard-Try, ALacoste, JMCordi, A S18616, a highly potent, spiroimidazoline agonist at alpha(2)-adrenoceptors: I. Receptor profile, antinociceptive and hypothermic actions in comparison with dexmedetomidine and clonidine. J Pharmacol Exp Ther295:1192-205 (2000) [PubMed]
More Info.:Get all data from this article
 
Nischarin
Name:Nischarin
Synonyms:Imidazoline I1
Type:Enzyme Catalytic Domain
Mol. Mass.:163227.58
Organism:BOVINE
Description:L8IEU8
Residue:1474
Sequence:
VYIIQITDGSHEWTVKHRYSDFHDLHEKLVAEKKIDRSLLPPKKIIGKNSRSLVEKREKD
LEIYLQTLLATFPDVAPRVLAQFLHFHFYEINGITAALAEELFEKGEQLLGAGEVFAIGP
LQLYAVTEQLQQGKPTCASGDAKTDLGHILDFTCRLKYLKVSGTEGPFGTSNIQEQLLPF
DLSIFKSLHQVEISHCDARRIRGLVASKPTLATMSVRFSATSMKEVLVPEASEFDEWEPA
GAALEGPVTAVIPTWQALTALDLSHNSISEIDDSVKLIPKIEFLDLSHNGVLVMNNLQHL
YNLVHVDLSYNKLSSLEGAHTKLGNIKTLNLAGNLLRHLSGLHKLYSLVNLDLSDNRIEQ
MEEVRSIGSLPCLEHVALLNNPLSIIPDYRTKVLAQFGERASEVCLDNTVTTEKELDTVE
VLKAIQKAKEVKSKLSNPEKKVSEDSRLSAAPCVRPSSSPPSAAPTSASLPQPILSNQGI
MFVQEEALASSLSSTDSLTPEDRSIVGGCSDSLESIPAGQAPSDDLRDVPGAVGGVSPEH
AEPEVQVVPGSGQIIFLPFTCIGYTATNQDFIQRLSTLIRQAIERQLPAWIEAANQREEG
QGEQGEEEEEEEDVAENRYFEMGPPDTEEEEEGGPGEEEEEEEEEEAEEERLALEWALGA
DEDFLLEHIRILKVLWCFLIHVQGSIRQFAACLVLTDFGIAVFEIPHQESRGSSQHILSS
LRFVFCFPHGDLTEFGFLMPELCLVLKVRHSENTLFIISDAAHLHEFHADLRACFAPQHM
AMLCSPVLYGSHTSLQEFLRQLLTFYKVAGGCQERSQGCFPVYLVYSDKRMVQTAAGDYS
GNIEWASCTLCSAVRRSCCAPSEASAAIPYWLLLTPQHLNVIKADFNPMPNRGTHNCRNR
NSFKLSRVPLSTVLLDPTRSCTQPRGAFADGHVLELLVGYRFVTAIFVLPHEKFHFLRIY
NQLRASLQDLKTVVIAKTPATGGGPQSPLVDGQPAESRASSDQNLQEAPAETTAPALVEA
PALTPGEASAPSPAKTPAPVEASVPALVPVEVPAEAEASAEIPVEALAQAEAPAQYPSEP
LIRSMSEDNQIPSHLPACPSLRHIASLRGRAVVEFFHSSIAEVENEELRHLLWSSVVFYQ
MPGLEVTACVLLSTKAVYFVLHDGLRRYFSEPLQDFWHQKNTDYNNSPFHISQCFVLKLS
DLQVVNVGLFDQYFRLTGSCPAQVVTCLTRDSYLTHCFLQHLMAVLSLLERTPSPEPVDK
DFYSEFGNKTTGKMENYELIHSSRVKFTYPSEEEVGDLTFTVAQKMAAPEKAPALSILLC
VQAFQVGSPQPGRCRGLLRPKTLLLTSAEIFLLDEDFVHYPLPEFAKEPPQRDRYRLDDG
RRVRDLDRVLMGYQTYPQALTLVFDDVQGHDLMGSVTLDHFGEVPGGPARGGQGREVQWQ
VFVPSAESREKLISLLARQWEALCGRELPVELTG
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50016897
n/a
NameBDBM50016897
Synonyms:2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) | 2-(2,6-dichloroanilino)-2-imidazoline | CLONIDINE | N-(2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine | clonidine (amino form)
TypeSmall organic molecule
Emp. Form.C9H9Cl2N3
Mol. Mass.230.094
SMILESClc1cccc(Cl)c1\[#7]=[#6]-1\[#7]-[#6]-[#6]-[#7]-1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: