Reaction Details | |||
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Target | Glutamate receptor 3 | ||
Ligand | BDBM50096327 | ||
Substrate/Competitor | n/a | ||
Ki | 25±n/a nM | ||
Comments | PDSP_576 | ||
Citation | Menniti, FS; Chenard, BL; Collins, MB; Ducat, MF; Elliott, ML; Ewing, FE; Huang, JI; Kelly, KA; Lazzaro, JT; Pagnozzi, MJ; Weeks, JL; Welch, WM; White, WF Characterization of the binding site for a novel class of noncompetitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonists. Mol Pharmacol58:1310-7 (2000) [PubMed] Article | ||
More Info.: | Get all data from this article | ||
Glutamate receptor 3 | |||
Name: | Glutamate receptor 3 | ||
Synonyms: | GRIA3_RAT | Glur3 | Glutamate receptor 3 | Glutamate receptor ionotropic, AMPA 3 | Glutamate-AMPA | Gria3 | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 100383.57 | ||
Organism: | RAT | ||
Description: | Glutamate-AMPA GRIA3 RAT::P19492 | ||
Residue: | 888 | ||
Sequence: |
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BDBM50096327 | |||
n/a | |||
Name | BDBM50096327 | ||
Synonyms: | (R)-3-(2-Chloro-phenyl)-2-[(E)-2-(6-diethylaminomethyl-pyridin-2-yl)-vinyl]-6-fluoro-3H-quinazolin-4-one | (S)-3-(2-Chloro-phenyl)-2-[(E)-2-(6-diethylaminomethyl-pyridin-2-yl)-vinyl]-6-fluoro-3H-quinazolin-4-one | 3-(2-Chloro-phenyl)-2-[(E)-2-(6-diethylaminomethyl-pyridin-2-yl)-vinyl]-6-fluoro-3H-quinazolin-4-one | CHEMBL301759 | CP-465022 | ||
Type | Small organic molecule | ||
Emp. Form. | C26H24ClFN4O | ||
Mol. Mass. | 462.946 | ||
SMILES | CCN(CC)Cc1cccc(\C=C\c2nc3ccc(F)cc3c(=O)n2-c2ccccc2Cl)n1 |(13.07,-4.53,;11.73,-3.76,;10.41,-4.56,;10.42,-6.09,;9.1,-6.86,;9.06,-3.81,;7.73,-4.59,;7.75,-6.13,;6.41,-6.9,;5.09,-6.14,;5.09,-4.6,;3.74,-3.86,;3.74,-2.32,;2.4,-1.55,;1.06,-2.32,;-.3,-1.55,;-1.63,-2.32,;-2.95,-1.55,;-2.95,-.01,;-4.31,.76,;-1.63,.76,;-.3,-.01,;1.05,.81,;1.03,2.35,;2.4,.04,;3.72,.81,;3.72,2.32,;5.04,3.12,;6.37,2.35,;6.37,.81,;5.07,.04,;5.06,-1.52,;6.4,-3.82,)| | ||
Structure |