| Reaction Details |
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 | Report a problem with these data |
| Target | Diacylglycerol O-acyltransferase 2 |
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| Ligand | BDBM276752 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro DGAT2 Assay |
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| pH | 7.4±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 13.5±n/a nM |
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| Comments | extracted |
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| Citation |  Boehm, M; Cabral, S; Dowling, MS; Futatsugi, K; Huard, K; Lee, EC; Londregan, AT; Polivkova, J; Price, DA; Li, Q Diacylglycerol acyl transferase 2 inhibitors US Patent US10071992 Publication Date 9/11/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Diacylglycerol O-acyltransferase 2 |
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| Name: | Diacylglycerol O-acyltransferase 2 |
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| Synonyms: | ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase |
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| Type: | Multi-pass membrane protein |
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| Mol. Mass.: | 43848.90 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96PD7 |
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| Residue: | 388 |
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| Sequence: | MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLN
RSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKG
GRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATE
VSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGG
AAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQ
KKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHT
MYMEALVKLFDKHKTKFGLPETEVLEVN
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| BDBM276752 |
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| n/a |
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| Name | BDBM276752 |
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| Synonyms: | 2-(5-((3-ethoxypyridin- 2-yl)oxy)pyridin-3-yl)-N-(3- methyl-1,1-dioxidotetra- hydrothiophen-3-yl) pyrimidine-5-carboxamide | US10071992, Example 3.1 | US11034678, Example 3.1 | US11065249, WO2018033832-Ex.-3.1 | WO2018033832, Ex. 3.1 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H23N5O5S |
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| Mol. Mass. | 469.514 |
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| SMILES | CCOc1cccnc1Oc1cncc(c1)-c1ncc(cn1)C(=O)NC1(C)CCS(=O)(=O)C1 |
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| Structure | 
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