| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Diacylglycerol O-acyltransferase 2 |
|---|
| Ligand | BDBM276760 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | In Vitro DGAT2 Assay |
|---|
| pH | 7.4±n/a |
|---|
| Temperature | 298.15±n/a K |
|---|
| IC50 | 20.9±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Boehm M; Cabral S; Dowling MS; Futatsugi K; Huard K; Lee EC; Londregan AT; Polivkova J; Price DA; Li Q Diacylglycerol acyl transferase 2 inhibitors US Patent US10071992 Publication Date 9/11/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Diacylglycerol O-acyltransferase 2 |
|---|
| Name: | Diacylglycerol O-acyltransferase 2 |
|---|
| Synonyms: | ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase |
|---|
| Type: | Multi-pass membrane protein |
|---|
| Mol. Mass.: | 43848.90 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q96PD7 |
|---|
| Residue: | 388 |
|---|
| Sequence: | MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLN
RSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKG
GRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATE
VSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGG
AAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQ
KKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHT
MYMEALVKLFDKHKTKFGLPETEVLEVN
|
|
|
|---|
| BDBM276760 |
|---|
| n/a |
|---|
| Name | BDBM276760 |
|---|
| Synonyms: | US10071992, Example 6a |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H23N5O5 |
|---|
| Mol. Mass. | 437.4485 |
|---|
| SMILES | CCOc1cccnc1Oc1cncc(c1)-c1ncc(cn1)C(=O)NC1(CO)CCOC1 |
|---|
| Structure | 
|
|---|
Search and Browse
