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TargetDiacylglycerol O-acyltransferase 2
LigandBDBM276763
Substrate/Competitorn/a
Meas. Tech.In Vitro DGAT2 Assay
pH7.4±n/a
Temperature298.15±n/a K
IC50 3.70±n/a nM
Commentsextracted
Citation Boehm MCabral SDowling MSFutatsugi KHuard KLee ECLondregan ATPolivkova JPrice DALi Q Diacylglycerol acyl transferase 2 inhibitors US Patent  US10071992 Publication Date 9/11/2018
More Info.:Get all data from this article,  Assay Method
 
Diacylglycerol O-acyltransferase 2
Name:Diacylglycerol O-acyltransferase 2
Synonyms:ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase
Type:Multi-pass membrane protein
Mol. Mass.:43848.90
Organism:Homo sapiens (Human)
Description:Q96PD7
Residue:388
Sequence:
MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLN
RSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKG
GRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATE
VSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGG
AAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQ
KKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHT
MYMEALVKLFDKHKTKFGLPETEVLEVN
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BDBM276763
n/a
NameBDBM276763
Synonyms:US10071992, Example 8
TypeSmall organic molecule
Emp. Form.C21H20FN5O4
Mol. Mass.425.413
SMILESCCOc1cc(F)cnc1Oc1cncc(c1)-c1ncc(cn1)C(=O)N[C@H]1CCOC1 |r|
Structure
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