| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M4 |
|---|
| Ligand | BDBM85818 |
|---|
| Substrate/Competitor | n/a |
|---|
| Ki | 5410±n/a nM |
|---|
| Comments | PDSP_2009 |
|---|
| Citation |  Roth, BL; Ernsberger, P; Steinberg, SA; Rao, S; Rauser, L; Savage, J; Hufeisen, S; Berridge, MS; Muzic, RF The in vitro pharmacology of the beta-adrenergic receptor pet ligand (s)-fluorocarazolol reveals high affinity for cloned beta-adrenergic receptors and moderate affinity for the human 5-HT1A receptor. Psychopharmacology (Berl)157:111-4 (2001) [PubMed] Article |
|---|
| More Info.: | Get all data from this article |
|---|
| |
| Muscarinic acetylcholine receptor M4 |
|---|
| Name: | Muscarinic acetylcholine receptor M4 |
|---|
| Synonyms: | ACM4_HUMAN | CHRM4 | Cholinergic, muscarinic M4 | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M2 and M4 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 53079.31 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Cholinergic, muscarinic M4 CHRM4 HUMAN M3::P08173 |
|---|
| Residue: | 479 |
|---|
| Sequence: | MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVN
RQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASV
MNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTV
PDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAK
TLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGS
ATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIV
PATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMV
LVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
|
|
|
|---|
| BDBM85818 |
|---|
| n/a |
|---|
| Name | BDBM85818 |
|---|
| Synonyms: | Fluorocarazolol,(R) | Fluorocarazolol,(S) |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H21FN2O2 |
|---|
| Mol. Mass. | 316.3699 |
|---|
| SMILES | CC(CF)NCC(O)COc1cccc2[nH]c3ccccc3c12 |
|---|
| Structure | 
|
|---|
Search and Browse
