| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histamine H3 receptor |
|---|
| Ligand | BDBM22911 |
|---|
| Substrate/Competitor | n/a |
|---|
| Ki | 1.62±n/a nM |
|---|
| Comments | PDSP_968 |
|---|
| Citation |  Wieland, K; Bongers, G; Yamamoto, Y; Hashimoto, T; Yamatodani, A; Menge, WM; Timmerman, H; Lovenberg, TW; Leurs, R Constitutive activity of histamine h(3) receptors stably expressed in SK-N-MC cells: display of agonism and inverse agonism by H(3) antagonists. J Pharmacol Exp Ther299:908-14 (2001) [PubMed] |
|---|
| More Info.: | Get all data from this article |
|---|
| |
| Histamine H3 receptor |
|---|
| Name: | Histamine H3 receptor |
|---|
| Synonyms: | G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4) |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 48691.47 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Binding assays were using CHO cells stably expressing hH3R receptors. |
|---|
| Residue: | 445 |
|---|
| Sequence: | MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS
SAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAA
GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSV
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL
AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR
RAFTKLLCPQKLKIQPHSSLEHCWK
|
|
|
|---|
| BDBM22911 |
|---|
| n/a |
|---|
| Name | BDBM22911 |
|---|
| Synonyms: | 2-(3H-imidazol-4-yl)ethylsulfanylmethanimidamide | CHEMBL19439 | CHEMBL544911 | Imetit | {[2-(1H-imidazol-4-yl)ethyl]sulfanyl}methanimidamide |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C6H10N4S |
|---|
| Mol. Mass. | 170.235 |
|---|
| SMILES | NC(=N)SCCc1cnc[nH]1 |
|---|
| Structure | 
|
|---|
Search and Browse
