| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Alpha-1A adrenergic receptor |
|---|
| Ligand | BDBM84745 |
|---|
| Substrate/Competitor | n/a |
|---|
| Ki | 1000±n/a nM |
|---|
| Comments | PDSP_763 |
|---|
| Citation |  Bymaster, FP; Dreshfield-Ahmad, LJ; Threlkeld, PG; Shaw, JL; Thompson, L; Nelson, DL; Hemrick-Luecke, SK; Wong, DT Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors. Neuropsychopharmacology25:871-80 (2001) [PubMed] Article |
|---|
| More Info.: | Get all data from this article |
|---|
| |
| Alpha-1A adrenergic receptor |
|---|
| Name: | Alpha-1A adrenergic receptor |
|---|
| Synonyms: | ADA1A_RAT | Adra1a | Adra1c | Alpha-1 adrenoreceptor | Alpha-1A adrenoceptor | Alpha-1A adrenoreceptor | Alpha-1C adrenergic receptor | adrenergic Alpha1A |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 51620.15 |
|---|
| Organism: | Rattus norvegicus (Rat) |
|---|
| Description: | P43140 |
|---|
| Residue: | 466 |
|---|
| Sequence: | MVLLSENASEGSNCTHPPAPVNISKAILLGVILGGLIIFGVLGNILVILSVACHRHLHSV
THYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGLCII
SIDRYIGVSYPLRYPTIVTQRRGVRALLCVWVLSLVISIGPLFGWRQPAPEDETICQINE
EPGYVLFSALGSFYVPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
VPAEGGGVSSAKNKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD
FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRRQSSKHALGYTL
HPPSQALEGQHRDMVRIPVGSGETFYKISKTDGVCEWKFFSSMPQGSARITVPKDQSACT
TARVRSKSFLQVCCCVGSSAPRPEENHQVPTIKIHTISLGENGEEV
|
|
|
|---|
| BDBM84745 |
|---|
| n/a |
|---|
| Name | BDBM84745 |
|---|
| Synonyms: | CAS_136434-34-9 | DULOXETINE | LY-248686 | LY248686 | USRE49340, Rank 5 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H19NOS |
|---|
| Mol. Mass. | 297.415 |
|---|
| SMILES | CNCC[C@H](Oc1cccc2ccccc12)c1cccs1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
