| Reaction Details |
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 | Report a problem with these data |
| Target | Neuromedin-K receptor |
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| Ligand | BDBM85845 |
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| Substrate/Competitor | n/a |
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| Ki | 1.6±n/a nM |
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| Comments | PDSP_2451 |
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| Citation |  Hay, DW; Giardina, GA; Griswold, DE; Underwood, DC; Kotzer, CJ; Bush, B; Potts, W; Sandhu, P; Lundberg, D; Foley, JJ; Schmidt, DB; Martin, LD; Kilian, D; Legos, JJ; Barone, FC; Luttmann, MA; Grugni, M; Raveglia, LF; Sarau, HM Nonpeptide tachykinin receptor antagonists. III. SB 235375, a low central nervous system-penetrant, potent and selective neurokinin-3 receptor antagonist, inhibits citric acid-induced cough and airways hyper-reactivity in guinea pigs. J Pharmacol Exp Ther300:314-23 (2002) [PubMed] Article |
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| More Info.: | Get all data from this article |
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| Neuromedin-K receptor |
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| Name: | Neuromedin-K receptor |
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| Synonyms: | NK3R_CAVPO | Neurokinin 3 receptor | Neurokinin NK3 | Neuromedin-K receptor | TACR3 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 49456.44 |
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| Organism: | GUINEA PIG |
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| Description: | Neurokinin NK3 TACR3 GUINEA PIG::P30098 |
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| Residue: | 440 |
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| Sequence: | MASPAGNLSAWPGWGWPPPAALRNLTSSPAPTASPSPAPSWTPSPRPGPAHPFLQPPWAV
ALWSLAYGAVVAVAVLGNLVVIWIVLAHKRMRTVTNSFLVNLAFADAAMAALNALVNFIY
ALHGEWYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPLKPRLSATATRIVIG
SIWILAFLLAFPQCLYSKIKVMPGRTLCYVQWPEGSRQHFTYHMIVIVLVYCFPLLIMGI
TYTIVGITLWGGEIPGDTCDKYQEQLKAKRKVVKMMIIVVVTFAICWLPYHIYFILTAIY
QQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIHVSSYDEL
ELKATRLHPMRQSSLYTVTRMESMSVVFDSNDGDSARSSHQKRGTTRDVGSNVCSRRNSK
STSTTASFVSSSHMSVEEGS
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| BDBM85845 |
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| n/a |
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| Name | BDBM85845 |
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| Synonyms: | N-[(S)-1-Phenylpropyl]-2-phenyl-3-(carboxymethoxy)quinoline-4-carboxamide | SB 235375 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H24N2O4 |
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| Mol. Mass. | 440.4905 |
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| SMILES | CC[C@H](NC(=O)c1c(OCC(O)=O)c(nc2ccccc12)-c1ccccc1)c1ccccc1 |
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| Structure | 
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