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TargetTACR3
LigandBDBM85845
Substrate/Competitorn/a
Ki 1.6±n/a nM
CommentsPDSP_2451
Citation Hay DWGiardina GAGriswold DEUnderwood DCKotzer CJBush BPotts WSandhu PLundberg DFoley JJSchmidt DBMartin LDKilian DLegos JJBarone FCLuttmann MAGrugni MRaveglia LFSarau HM Nonpeptide tachykinin receptor antagonists. III. SB 235375, a low central nervous system-penetrant, potent and selective neurokinin-3 receptor antagonist, inhibits citric acid-induced cough and airways hyper-reactivity in guinea pigs. J Pharmacol Exp Ther 300:314-23 (2002) [PubMed]  Article
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TACR3
Name:Neurokinin 3 receptor
Synonyms:Neurokinin NK3 | Neuromedin-K receptor
Type:Enzyme Catalytic Domain
Mol. Mass.:49456.44
Organism:GUINEA PIG
Description:Neurokinin NK3 TACR3 GUINEA PIG::P30098
Residue:440
Sequence:
MASPAGNLSAWPGWGWPPPAALRNLTSSPAPTASPSPAPSWTPSPRPGPAHPFLQPPWAV
ALWSLAYGAVVAVAVLGNLVVIWIVLAHKRMRTVTNSFLVNLAFADAAMAALNALVNFIY
ALHGEWYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPLKPRLSATATRIVIG
SIWILAFLLAFPQCLYSKIKVMPGRTLCYVQWPEGSRQHFTYHMIVIVLVYCFPLLIMGI
TYTIVGITLWGGEIPGDTCDKYQEQLKAKRKVVKMMIIVVVTFAICWLPYHIYFILTAIY
QQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIHVSSYDEL
ELKATRLHPMRQSSLYTVTRMESMSVVFDSNDGDSARSSHQKRGTTRDVGSNVCSRRNSK
STSTTASFVSSSHMSVEEGS
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  Blast E-value cutoff:
BDBM85845
n/a
NameBDBM85845
Synonyms:N-[(S)-1-Phenylpropyl]-2-phenyl-3-(carboxymethoxy)quinoline-4-carboxamide | SB 235375
TypeSmall organic molecule
Emp. Form.C27H24N2O4
Mol. Mass.440.4905
SMILESCC[C@H](NC(=O)c1c(OCC(O)=O)c(nc2ccccc12)-c1ccccc1)c1ccccc1
Structure
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