| Reaction Details |
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 | Report a problem with these data |
| Target | Melanin-concentrating hormone receptor 1 |
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| Ligand | BDBM50150715 |
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| Substrate/Competitor | n/a |
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| Ki | 8.6±n/a nM |
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| Comments | PDSP_2491 |
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| Citation |  Takekawa, S; Asami, A; Ishihara, Y; Terauchi, J; Kato, K; Shimomura, Y; Mori, M; Murakoshi, H; Kato, K; Suzuki, N; Nishimura, O; Fujino, M T-226296: a novel, orally active and selective melanin-concentrating hormone receptor antagonist. Eur J Pharmacol438:129-35 (2002) [PubMed] Article |
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| More Info.: | Get all data from this article |
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| Melanin-concentrating hormone receptor 1 |
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| Name: | Melanin-concentrating hormone receptor 1 |
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| Synonyms: | G-protein coupled receptor 24 | Gpr24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCH1R | MCHR | MCHR-1 | MCHR1_RAT | Mchr1 | Melanin Concentrating Hormone 1 | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 | SLC-1 | Slc1 | Somatostatin receptor-like protein |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 39075.64 |
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| Organism: | RAT |
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| Description: | Melanin Concentrating Hormone 1 GPR24 RAT::P97639 |
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| Residue: | 353 |
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| Sequence: | MDLQTSLLSTGPNASNISDGQDNLTLPGSPPRTGSVSYINIIMPSVFGTICLLGIVGNST
VIFAVVKKSKLHWCSNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLIT
AMDANSQFTSTYILTAMTIDRYLATVHPISSTKFRKPSMATLVICLLWALSFISITPVWL
YARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVKILQRMTSSVA
PASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLG
YANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRTVSNAQTADEERTESKGT
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| BDBM50150715 |
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| n/a |
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| Name | BDBM50150715 |
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| Synonyms: | 4''-Fluoro-biphenyl-4-carboxylic acid (6-dimethylaminomethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-amide | 4'-fluoro-biphenyl-4-carboxylic acid (6-dimethylaminomethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-amide | CHEMBL178707 | N-(6-((dimethylamino)methyl)-5,6,7,8-tetrahydronaphthalen-2-yl)-4'-fluorobiphenyl-4-carboxamide | T-226296 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H27FN2O |
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| Mol. Mass. | 402.5038 |
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| SMILES | CN(C)CC1CCc2cc(NC(=O)c3ccc(cc3)-c3ccc(F)cc3)ccc2C1 |
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| Structure | 
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