| Reaction Details |
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 | Report a problem with these data |
| Target | Arachidonate 12-lipoxygenase, 12R-type |
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| Ligand | BDBM86012 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| pH | 8±0 |
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| Temperature | 298.15±0 K |
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| Ki | 7.17e+4± 5e+2 nM |
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| Citation |  Hasan, A; Khan, KM; Sher, M; Maharvi, GM; Nawaz, SA; Choudhary, MI; Atta-ur-Rahman, A; Supuran, CT Synthesis and inhibitory potential towards acetylcholinesterase, butyrylcholinesterase and lipoxygenase of some variably substituted chalcones. J Enzyme Inhib Med Chem20:41-7 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Arachidonate 12-lipoxygenase, 12R-type |
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| Name: | Arachidonate 12-lipoxygenase, 12R-type |
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| Synonyms: | ALOX12B | LX12B_HUMAN | Lipoxygenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 80366.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O75342 |
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| Residue: | 701 |
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| Sequence: | MATYKVRVATGTDLLSGTRDSISLTIVGTQGESHKQLLNHFGRDFATGAVGQYTVQCPQD
LGELIIIRLHKERYAFFPKDPWYCNYVQICAPNGRIYHFPAYQWMDGYETLALREATGKT
TADDSLPVLLEHRKEEIRAKQDFYHWRVFLPGLPSYVHIPSYRPPVRRHRNPNRPEWNGY
IPGFPILINFKATKFLNLNLRYSFLKTASFFVRLGPMALAFKVRGLLDCKHSWKRLKDIR
KIFPGKKSVVSEYVAEHWAEDTFFGYQYLNGVNPGLIRRCTRIPDKFPVTDDMVAPFLGE
GTCLQAELEKGNIYLADYRIMEGIPTVELSGRKQHHCAPLCLLHFGPEGKMMPIAIQLSQ
TPGPDCPIFLPSDSEWDWLLAKTWVRYAEFYSHEAIAHLLETHLIAEAFCLALLRNLPMC
HPLYKLLIPHTRYTVQINSIGRAVLLNEGGLSAKGMSLGVEGFAGVMVRALSELTYDSLY
LPNDFVERGVQDLPGYYYRDDSLAVWNALEKYVTEIITYYYPSDAAVEGDPELQSWVQEI
FKECLLGRESSGFPRCLRTVPELIRYVTIVIYTCSAKHAAVNTGQMEFTAWMPNFPASMR
NPPIQTKGLTTLETFMDTLPDVKTTCITLLVLWTLSREPDDRRPLGHFPDIHFVEEAPRR
SIEAFRQRLNQISHDIRQRNKCLPIPYYYLDPVLIENSISI
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| BDBM86012 |
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| n/a |
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| Name | BDBM86012 |
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| Synonyms: | Chalcone, 11 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H10Cl2O2 |
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| Mol. Mass. | 293.145 |
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| SMILES | Oc1ccc(Cl)cc1C(=O)\C=C\c1ccc(Cl)cc1 |
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| Structure | 
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