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TargetSerine/threonine-protein kinase TBK1
LigandBDBM277010
Substrate/Competitorn/a
Meas. Tech.Biological Assay for TBK1 and IKKs
pH7±n/a
IC50 1.16±n/a nM
Commentsextracted
Citation Du, ZGuerrero, JAKaplan, JAKnox, Jr., JENaduthambi, DPhillips, BWVenkataramani, CWang, PWatkins, WJZablocki, J Tank-binding kinase inhibitor compounds US Patent US10072001 Publication Date 9/11/2018
More Info.:Get all data from this article,  Assay Method
 
Serine/threonine-protein kinase TBK1
Name:Serine/threonine-protein kinase TBK1
Synonyms:NAK | NF-kappa-B-activating kinase | Protein cereblon/Serine/threonine-protein kinase TBK1 | T2K | TANK-binding kinase 1 (TBK-1) | TANK-binding kinase 1 (TBK1) | TBK1 | TBK1_HUMAN
Type:protein
Mol. Mass.:83645.20
Organism:Homo sapiens (Human)
Description:Q9UHD2
Residue:729
Sequence:
MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLK
KLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV
GGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYL
HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG
KPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFA
ETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLV
LEPGRLAQHFPKTTEENPIFVVSREPLNTIGLIYEKISLPKVHPRYDLDGDASMAKAITG
VVCYACRIASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEKTVK
VYEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAHQE
GTHPKDRNVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMTH
FTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNELQETLPQ
KMFTASSGIKHTMTPIYPSSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFGSLTMD
GGLRNVDCL
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  Blast E-value cutoff:
BDBM277010
n/a
NameBDBM277010
Synonyms:US10072001, Example 187 | US10259811, Example 187
TypeSmall organic molecule
Emp. Form.C30H30N6O3
Mol. Mass.522.5976
SMILESCN1CCN(CC1)C(=O)c1ccc(cc1)-c1cc2c(ncnc2[nH]1)-c1ccc(OC2CCOCC2)c(c1)C#N
Structure
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