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Targetneuronal acetylcholine receptor subunit alpha-2
LigandBDBM86042
Substrate/Competitorn/a
Ki 0.028±n/a nM
CommentsPDSP_2905
Citation Avalos, MParker, MJMaddox, FNCarroll, FILuetje, CW Effects of pyridine ring substitutions on affinity, efficacy, and subtype selectivity of neuronal nicotinic receptor agonist epibatidine. J Pharmacol Exp Ther302:1246-52 (2002) [PubMed]  Article
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neuronal acetylcholine receptor subunit alpha-2
Name:neuronal acetylcholine receptor subunit alpha-2
Synonyms:Cholinergic, Nicotinic Alpha2Beta2 | Cholinergic, Nicotinic Alpha2Beta4
Type:Enzyme Catalytic Domain
Mol. Mass.:59160.03
Organism:Xenopus
Description:A0A6I8T284
Residue:510
Sequence:
MENCMGGTLSILCWMITFTTVSCMERTRTHAEERLFKRLFTGYNRWSRPVPNTSDVVIVK
FGLSIAQLIDVDEKNQMMTTNVWLKQEWNDYKLRWNPADYDNVTSIRVPSEMIWIPDIVL
YNNADGEFAITHMTKAHLFHNGKVKWVPPAIYKSSCSIDVTFFPFDQQSCKMKFGSWTYD
KAWLDLESMERNVDLKDYWESGEWAIVNAVGKYNSKKYDCCTEIYPDITYYFIIRRLPLF
YTINLIIPCLLISCLTVLVFYLPSDCGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPL
IGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHKMPLWVRSVFLDHIPRWLFMKRPPAPV
EEVVSQYDAPELKLSTSKYWMETDVDDKWAEPEAELQTCHVRHMTTHNQSLQYRYDYNHH
VSGGQSQTPRHSSTETAESSFLLSPSVLKALEGVHYIANHLRAEDADFSVKEDWKYVAMV
IDRIFLWMFIIVCLLGTVGLFLPPFLAGMI
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BDBM86042
n/a
NameBDBM86042
Synonyms:NEP
TypeSmall organic molecule
Emp. Form.C11H14N2
Mol. Mass.174.2423
SMILESC1CC2NC1C[C@@H]2c1cccnc1 |r,TLB:7:6:0.1:3|
Structure
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