| Reaction Details |
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 | Report a problem with these data |
| Target | Substance-P receptor |
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| Ligand | BDBM50116078 |
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| Substrate/Competitor | n/a |
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| Ki | 1.3±n/a nM |
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| Comments | PDSP_3952 |
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| Citation |  Anthes, JC; Chapman, RW; Richard, C; Eckel, S; Corboz, M; Hey, JA; Fernandez, X; Greenfeder, S; McLeod, R; Sehring, S; Rizzo, C; Crawley, Y; Shih, NY; Piwinski, J; Reichard, G; Ting, P; Carruthers, N; Cuss, FM; Billah, M; Kreutner, W; Egan, RW SCH 206272: a potent, orally active tachykinin NK(1), NK(2), and NK(3) receptor antagonist. Eur J Pharmacol450:191-202 (2002) [PubMed] Article |
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| More Info.: | Get all data from this article |
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| Substance-P receptor |
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| Name: | Substance-P receptor |
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| Synonyms: | NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 46254.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25103 |
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| Residue: | 407 |
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| Sequence: | MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVC
MIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTIST
VVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
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| BDBM50116078 |
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| n/a |
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| Name | BDBM50116078 |
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| Synonyms: | 3,5-Dichloro-N-[3-(3,4-dichloro-phenyl)-2-methoxyimino-5-(3-methylcarbamoylmethyl-2-oxo-[1,4']bipiperidinyl-1'-yl)-pentyl]-N-ethyl-benzamide | CHEMBL66332 | SCH 206272 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H41Cl4N5O4 |
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| Mol. Mass. | 713.522 |
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| SMILES | CNC(=O)CC1CCCN(C2CCN(CC[C@@H](\C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N\OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O |
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| Structure | 
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