| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Neuromedin-K receptor |
|---|
| Ligand | BDBM85083 |
|---|
| Substrate/Competitor | n/a |
|---|
| Ki | 0.053±n/a nM |
|---|
| Comments | PDSP_1335 |
|---|
| Citation |  Emonds-Alt, X; Proietto, V; Steinberg, R; Oury-Donat, F; Vigé, X; Vilain, P; Naline, E; Daoui, S; Advenier, C; Le Fur, G; Maffrand, JP; Soubrié, P; Pascal, M SSR240600 [(R)-2-(1-[2-[4-[2-[3,5-bis(trifluoromethyl)phenyl]acetyl]-2-(3,4-dichlorophenyl)-2-morpholinyl]ethyl]- 4-piperidinyl)-2-methylpropanamide], a centrally active nonpeptide antagonist of the tachykinin neurokinin-1 receptor: I. biochemical and pharmacological characterization. J Pharmacol Exp Ther303:1171-9 (2002) [PubMed] Article |
|---|
| More Info.: | Get all data from this article |
|---|
| |
| Neuromedin-K receptor |
|---|
| Name: | Neuromedin-K receptor |
|---|
| Synonyms: | NK-3 receptor | NK-3R | NK3R_MOUSE | NKR | Neurokinin 3 receptor | Neurokinin B receptor | Neurokinin NK3 | Neuromedin-K receptor | Tac3r | Tachykinin receptor 3 | Tacr3 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 51047.50 |
|---|
| Organism: | mouse |
|---|
| Description: | P47937 |
|---|
| Residue: | 452 |
|---|
| Sequence: | MASVPTGENWTDGTAGVGSHTGNLSAALGITEWLALQAGNFSSALGLPVTSQAPSQVRAN
LTNQFVQPSWRIALWSLAYGLVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDAS
VAAFNTLVNFIYGVHSEWYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPLKP
RLSATATKIVIGSIWILAFLLAFPQCLYSKIKVMPGRTLCYVQWPEGPKQHFTYHIIVII
LVYCFPLLIMGVTYTIVGITLWGGEIPGDTCDKYHEQLKAKRKVVKMMIIVVVTFAICWL
PYHVYFILTAIYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRW
CPFIQVSSYDELELKTTRFHPTRQSSLYTVSRMESVTVLYDPSEGDPAKSSRKKRAVPRD
PSANGCSHREFKSASTTSSFISSPYTSVDEYS
|
|
|
|---|
| BDBM85083 |
|---|
| n/a |
|---|
| Name | BDBM85083 |
|---|
| Synonyms: | NKB [MePhe7] |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C56H81N13O14S2 |
|---|
| Mol. Mass. | 1224.451 |
|---|
| SMILES | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCSC)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(N)=O |
|---|
| Structure | 
|
|---|
Search and Browse
