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TargetTyrosine-protein kinase CSK
LigandBDBM50142887
Substrate/Competitorn/a
Ki 730±n/a nM
CommentsPDSP_6410
Citation Bain, J; McLauchlan, H; Elliott, M; Cohen, P The specificities of protein kinase inhibitors: an update. Biochem J371:199-204 (2003) [PubMed]  Article
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Tyrosine-protein kinase CSK
Name:Tyrosine-protein kinase CSK
Synonyms:C-SRC kinase | C-src tyrosine kinase | CSK | CSK_HUMAN | Protein-tyrosine kinase CYL | Tyrosine Kinase CSK
Type:Tyrosine-protein kinase
Mol. Mass.:50707.30
Organism:Homo sapiens (Human)
Description:P41240
Residue:450
Sequence:
MSAIQAAWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGII
PANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCV
SCDGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQ
DEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVM
TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE
AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALRE
KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMK
NCWHLDAAMRPSFLQLREQLEHIKTHELHL
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BDBM50142887
n/a
NameBDBM50142887
Synonyms:1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[3,4-d]pyrimidine | 1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine | 1-tert-butyl-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | 4-Amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine | 4-amino-5-(4-chlorophenyl)-7-(tert-butyl)pyrazolo[3,4-d]pyrimidine | AG-1879 | CHEMBL406845 | PP2 | US10544104, Compound 146 | US10688093, Compound PP2 (Pfizer) | US11701353, PP2 (Pfizer) | US9765037, Compound 146 | cid_4878
TypeSmall organic molecule
Emp. Form.C15H16ClN5
Mol. Mass.301.774
SMILESCC(C)(C)n1nc(-c2ccc(Cl)cc2)c2c(N)ncnc12
Structure
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