| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin B |
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| Ligand | BDBM86100 |
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| Substrate/Competitor | BDBM16498 |
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| Meas. Tech. | Cathepsin Inhibition Assay |
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| pH | 6±0 |
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| Temperature | 296.15±0 K |
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| Ki | >1.00e+5±n/a nM |
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| Citation |  Yadav, MR; Shinde, AK; Chouhan, BS; Giridhar, R; Menard, R Peptidomimetic 2-cyanopyrrolidines as potent selective cathepsin L inhibitors. J Enzyme Inhib Med Chem23:190-7 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Cathepsin B |
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| Name: | Cathepsin B |
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| Synonyms: | APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 37819.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_63102437 |
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| Residue: | 339 |
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| Sequence: | MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCG
TFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDR
ICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCR
PYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIM
AEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSW
NTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
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| BDBM86100 |
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| BDBM16498 |
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| Name | BDBM86100 |
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| Synonyms: | 2-Cyanopyrrolidine Derivative, 29 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H21N3O2 |
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| Mol. Mass. | 347.4103 |
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| SMILES | O=C(NC(Cc1ccccc1)C(=O)N1CCC[C@H]1C#N)c1ccccc1 |r| |
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| Structure | 
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