Reaction Details |
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Target | L-lactate dehydrogenase A chain |
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Ligand | BDBM86115 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Enzyme Assay |
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pH | 7.5±0 |
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Temperature | 294.15±0 K |
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IC50 | >5.00e+5±n/a nM |
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Citation | Ward, RA; Brassington, C; Breeze, AL; Caputo, A; Critchlow, S; Davies, G; Goodwin, L; Hassall, G; Greenwood, R; Holdgate, GA; Mrosek, M; Norman, RA; Pearson, S; Tart, J; Tucker, JA; Vogtherr, M; Whittaker, D; Wingfield, J; Winter, J; Hudson, K Design and synthesis of novel lactate dehydrogenase a inhibitors by fragment-based lead generation. J Med Chem55:3285-306 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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L-lactate dehydrogenase A chain |
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Name: | L-lactate dehydrogenase A chain |
Synonyms: | L-lactate dehydrogenase A | L-lactate dehydrogenase A chain | LDHA_RAT | Ldh-1 | Ldh1 | Ldha |
Type: | Protein |
Mol. Mass.: | 36456.12 |
Organism: | Rattus norvegicus (Rat) |
Description: | P04642::PDB Codes: 4ajl, 4aj2, 4aje, 4aji, 4ajk, 4ajh, 4ajl, 4al4, 4ajh, 4ajo |
Residue: | 332 |
Sequence: | MAALKDQLIVNLLKEEQVPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKG
EMMDLQHGSLFLKTPKIVSSKDYSVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFI
IPNVVKYSPQCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGV
HPLSCHGWVLGEHGDSSVPVWSGVNVAGVSLKSLNPQLGTDADKEQWKDVHKQVVDSAYE
VIKLKGYTSWAIGLSVADLAESIMKNLRRVHPISTMIKGLYGIKEDVFLSVPCILGQNGI
SDVVKVTLTPDEEARLKKSADTLWGIQKELQF
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BDBM86115 |
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n/a |
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Name | BDBM86115 |
Synonyms: | LDHA Inhibitor, 9 |
Type | Small organic molecule |
Emp. Form. | C12H9N3O |
Mol. Mass. | 211.2194 |
SMILES | O=c1[nH]n(-c2ccccc2)c2ncccc12 |
Structure |
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