| Reaction Details |
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 | Report a problem with these data |
| Target | L-lactate dehydrogenase A chain |
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| Ligand | BDBM50078827 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Assay |
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| pH | 7.5±0 |
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| Temperature | 294.15±0 K |
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| IC50 | >5.00e+5±n/a nM |
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| Citation |  Ward, RA; Brassington, C; Breeze, AL; Caputo, A; Critchlow, S; Davies, G; Goodwin, L; Hassall, G; Greenwood, R; Holdgate, GA; Mrosek, M; Norman, RA; Pearson, S; Tart, J; Tucker, JA; Vogtherr, M; Whittaker, D; Wingfield, J; Winter, J; Hudson, K Design and synthesis of novel lactate dehydrogenase a inhibitors by fragment-based lead generation. J Med Chem55:3285-306 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| L-lactate dehydrogenase A chain |
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| Name: | L-lactate dehydrogenase A chain |
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| Synonyms: | L-lactate dehydrogenase A | L-lactate dehydrogenase A chain | LDHA_RAT | Ldh-1 | Ldh1 | Ldha |
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| Type: | Protein |
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| Mol. Mass.: | 36456.12 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P04642::PDB Codes: 4ajl, 4aj2, 4aje, 4aji, 4ajk, 4ajh, 4ajl, 4al4, 4ajh, 4ajo |
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| Residue: | 332 |
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| Sequence: | MAALKDQLIVNLLKEEQVPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKG
EMMDLQHGSLFLKTPKIVSSKDYSVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFI
IPNVVKYSPQCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGV
HPLSCHGWVLGEHGDSSVPVWSGVNVAGVSLKSLNPQLGTDADKEQWKDVHKQVVDSAYE
VIKLKGYTSWAIGLSVADLAESIMKNLRRVHPISTMIKGLYGIKEDVFLSVPCILGQNGI
SDVVKVTLTPDEEARLKKSADTLWGIQKELQF
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| BDBM50078827 |
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| n/a |
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| Name | BDBM50078827 |
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| Synonyms: | 2-(pyridin-3-yl)-1H-benzo[d]imidazole | 2-Pyridin-3-yl-1H-benzoimidazole | CHEMBL83103 | LDHA Inhibitor, 10 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H9N3 |
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| Mol. Mass. | 195.22 |
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| SMILES | c1ccc2[nH]c(nc2c1)-c1cccnc1 |
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| Structure | 
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