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TargetL-lactate dehydrogenase A chain
LigandBDBM86136
Substrate/Competitorn/a
Meas. Tech.Enzyme Assay
pH7.5±0
Temperature294.15±0 K
IC50 7.4e+3±n/a nM
Citation Ward, RABrassington, CBreeze, ALCaputo, ACritchlow, SDavies, GGoodwin, LHassall, GGreenwood, RHoldgate, GAMrosek, MNorman, RAPearson, STart, JTucker, JAVogtherr, MWhittaker, DWingfield, JWinter, JHudson, K Design and synthesis of novel lactate dehydrogenase a inhibitors by fragment-based lead generation. J Med Chem55:3285-306 (2012) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
L-lactate dehydrogenase A chain
Name:L-lactate dehydrogenase A chain
Synonyms:L-lactate dehydrogenase A | L-lactate dehydrogenase A chain | LDHA_RAT | Ldh-1 | Ldh1 | Ldha
Type:Protein
Mol. Mass.:36456.12
Organism:Rattus norvegicus (Rat)
Description:P04642::PDB Codes: 4ajl, 4aj2, 4aje, 4aji, 4ajk, 4ajh, 4ajl, 4al4, 4ajh, 4ajo
Residue:332
Sequence:
MAALKDQLIVNLLKEEQVPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKG
EMMDLQHGSLFLKTPKIVSSKDYSVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFI
IPNVVKYSPQCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGV
HPLSCHGWVLGEHGDSSVPVWSGVNVAGVSLKSLNPQLGTDADKEQWKDVHKQVVDSAYE
VIKLKGYTSWAIGLSVADLAESIMKNLRRVHPISTMIKGLYGIKEDVFLSVPCILGQNGI
SDVVKVTLTPDEEARLKKSADTLWGIQKELQF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM86136
n/a
NameBDBM86136
Synonyms:LDHA Inhibitor, 32
Typen/a
Emp. Form.C25H28N4O7S2
Mol. Mass.560.642
SMILESCCCSc1nc2ccc(NC(=O)CCNC(=O)NCCc3ccc(OC(C(O)=O)C(O)=O)cc3)cc2s1
Structure
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