| Reaction Details |
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 | Report a problem with these data |
| Target | Retinol-binding protein 4 |
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| Ligand | BDBM249474 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | TR-FRET Assay for Retinol-induced RBP4-TTR Interaction |
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| pH | 7.5±n/a |
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| IC50 | 2.88±n/a nM |
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| Comments | extracted |
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| Citation |  Petrukhin, K; Cioffi, C; Johnson, G; Allikmets, R; Freeman, E; Chen, P; Conlon, M; Zhu, L Substituted 4-phenylpiperidines, their preparation and use US Patent US10072016 Publication Date 9/11/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Retinol-binding protein 4 |
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| Name: | Retinol-binding protein 4 |
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| Synonyms: | PRBP | Plasma retinol-binding protein | RBP | RBP4 | RET4_HUMAN | Retinol-binding protein 4 | Retinol-binding protein 4 (RBP4) | spa binding assay for rbp4 |
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| Type: | Protein |
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| Mol. Mass.: | 23008.75 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P02753 |
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| Residue: | 201 |
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| Sequence: | MKWVWALLLLAALGSGRAERDCRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIV
AEFSVDETGQMSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGND
DHWIVDTDYDTYAVQYSCRLLNLDGTCADSYSFVFSRDPNGLPPEAQKIVRQRQEELCLA
RQYRLIVHNGYCDGRSERNLL
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| BDBM249474 |
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| n/a |
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| Name | BDBM249474 |
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| Synonyms: | US10072016, Compound 77 | US10407433, Compound 77 | US10913746, Compound 77 | US11649240, Compound 77 | US9434727, 73 | US9434727, 77 | US9777010, Compound 77 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H26F4N4O2 |
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| Mol. Mass. | 454.4611 |
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| SMILES | COCCN1CCc2c(C1)[nH]nc2C(=O)N1CCC(CC1)c1cccc(F)c1C(F)(F)F |
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| Structure | 
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