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Reaction Details
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TargetTransthyretin
LigandBDBM249541
Substrate/Competitorn/a
Meas. Tech.Scintillation Proximity RBP4 Binding Assay
pH7.4±n/a
Temperature298.15±n/a K
IC50 22.8±n/a nM
Commentsextracted
Citation Petrukhin, KCioffi, CJohnson, GAllikmets, RFreeman, EChen, PConlon, MZhu, L Substituted 4-phenylpiperidines, their preparation and use US Patent US10072016 Publication Date 9/11/2018
More Info.:Get all data from this article,  Assay Method
 
Transthyretin
Name:Transthyretin
Synonyms:ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:Enzyme
Mol. Mass.:15884.31
Organism:Homo sapiens (Human)
Description:P02766
Residue:147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDT
WEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDS
GPRRYTIAALLSPYSYSTTAVVTNPKE
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BDBM249541
n/a
NameBDBM249541
Synonyms:US10072016, Compound 139 | US10407433, Compound 139 | US10913746, Compound 139 | US11649240, Compound 139 | US9434727, 139 | US9777010, Compound 139
TypeSmall organic molecule
Emp. Form.C21H22F5N5O2
Mol. Mass.471.4237
SMILESCNC(=O)N1CCc2c(C1)[nH]nc2C(=O)N1CCC(CC1)c1cc(F)cc(F)c1C(F)(F)F
Structure
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