Reaction Details |
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Target | Transthyretin |
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Ligand | BDBM249541 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Scintillation Proximity RBP4 Binding Assay |
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pH | 7.4±n/a |
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Temperature | 298.15±n/a K |
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IC50 | 22.8±n/a nM |
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Comments | extracted |
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Citation | Petrukhin, K; Cioffi, C; Johnson, G; Allikmets, R; Freeman, E; Chen, P; Conlon, M; Zhu, L Substituted 4-phenylpiperidines, their preparation and use US Patent US10072016 Publication Date 9/11/2018 |
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More Info.: | Get all data from this article, Assay Method |
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Transthyretin |
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Name: | Transthyretin |
Synonyms: | ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR) |
Type: | Enzyme |
Mol. Mass.: | 15884.31 |
Organism: | Homo sapiens (Human) |
Description: | P02766 |
Residue: | 147 |
Sequence: | MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDT
WEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDS
GPRRYTIAALLSPYSYSTTAVVTNPKE
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BDBM249541 |
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n/a |
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Name | BDBM249541 |
Synonyms: | US10072016, Compound 139 | US10407433, Compound 139 | US10913746, Compound 139 | US11649240, Compound 139 | US9434727, 139 | US9777010, Compound 139 |
Type | Small organic molecule |
Emp. Form. | C21H22F5N5O2 |
Mol. Mass. | 471.4237 |
SMILES | CNC(=O)N1CCc2c(C1)[nH]nc2C(=O)N1CCC(CC1)c1cc(F)cc(F)c1C(F)(F)F |
Structure |
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