| Reaction Details |
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 | Report a problem with these data |
| Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
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| Ligand | BDBM50113382 |
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| Substrate/Competitor | n/a |
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| Ki | 1252.7±n/a nM |
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| Comments | PDSP_3037 |
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| Citation |  Zhao, Y; Zhang, HT; O'Donnell, JM Inhibitor binding to type 4 phosphodiesterase (PDE4) assessed using [3H]piclamilast and [3H]rolipram. J Pharmacol Exp Ther305:565-72 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article |
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| cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
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| Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
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| Synonyms: | DPDE4 | PDE4B_RAT | Pde4b | Phosphodiesterase 4B |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 83349.50 |
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| Organism: | RAT |
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| Description: | P14646 |
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| Residue: | 736 |
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| Sequence: | MKKSRSVMAVTADDNLKDYFECSLSKSYSSSSYTLGIDLWRGRRCCSGNLQLPPLSQRQS
ERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSSGLVL
HAAFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRIVR
NNFTLLTNLHGAPNKRSPAASQAPVTRVSLQEESYQKLAMETLEELDWCLDQLETIQTYR
SVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKK
KQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSH
NRPLTCIMYAIFQERDLLKTFKISSDTFVTYMMTLEDHYHSDVAYHNSLHAADVAQSTHV
LLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHL
AVGFKLLQEEHCDIFQNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTS
SGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEI
SPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSP
SPPLDERSRDCQGLMEKFQFELTLEEEDSEGPEKEGEGPNYFSSTKTLCVIDPENRDSLE
ETDIDIATEDKSLIDT
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| BDBM50113382 |
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| n/a |
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| Name | BDBM50113382 |
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| Synonyms: | 4-(2-(3-(cyclopentyloxy)-4-methoxyphenyl)-2-phenylethyl)pyridine | 4-[2-(3-Cyclopentyloxy-4-methoxy-phenyl)-2-phenyl-ethyl]-pyridine | CDP 840 | CHEMBL286334 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H27NO2 |
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| Mol. Mass. | 373.4874 |
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| SMILES | COc1ccc(cc1OC1CCCC1)C(Cc1ccncc1)c1ccccc1 |
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| Structure | 
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