| Reaction Details |
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 | Report a problem with these data |
| Target | Oxysterols receptor LXR-beta |
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| Ligand | BDBM86263 |
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| Substrate/Competitor | n/a |
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| Ki | 1100±n/a nM |
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| Comments | PDSP_6976 |
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| Citation |  Bramlett, KS; Houck, KA; Borchert, KM; Dowless, MS; Kulanthaivel, P; Zhang, Y; Beyer, TP; Schmidt, R; Thomas, JS; Michael, LF; Barr, R; Montrose, C; Eacho, PI; Cao, G; Burris, TP A natural product ligand of the oxysterol receptor, liver X receptor. J Pharmacol Exp Ther307:291-6 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article |
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| Oxysterols receptor LXR-beta |
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| Name: | Oxysterols receptor LXR-beta |
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| Synonyms: | LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 50978.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P55055 |
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| Residue: | 460 |
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| Sequence: | MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDW
VIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGA
RRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQ
SQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKR
SFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQI
ALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMR
RLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRM
LMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
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| BDBM86263 |
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| n/a |
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| Name | BDBM86263 |
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| Synonyms: | CAS_57186-25-1 | NSC_0 | paxilline |
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| Type | Small organic molecule |
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| Emp. Form. | C27H33NO4 |
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| Mol. Mass. | 435.5552 |
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| SMILES | CC(C)(O)C1OC2CCC3(C)C4(C)C(Cc5c4[nH]c4ccccc54)CCC3(O)C2=CC1=O |c:33| |
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| Structure | 
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