Reaction Details |
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Target | 5-hydroxytryptamine receptor 6 |
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Ligand | BDBM78940 |
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Substrate/Competitor | n/a |
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Ki | 0.56±n/a nM |
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Comments | PDSP_1219 |
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Citation | Hirst, WD; Abrahamsen, B; Blaney, FE; Calver, AR; Aloj, L; Price, GW; Medhurst, AD Differences in the central nervous system distribution and pharmacology of the mouse 5-hydroxytryptamine-6 receptor compared with rat and human receptors investigated by radioligand binding, site-directed mutagenesis, and molecular modeling. Mol Pharmacol64:1295-308 (2003) [PubMed] Article |
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More Info.: | Get all data from this article |
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5-hydroxytryptamine receptor 6 |
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Name: | 5-hydroxytryptamine receptor 6 |
Synonyms: | 5-HT6 | 5-hydroxytryptamine receptor 6 | 5HT6R_MOUSE | Htr6 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 47012.98 |
Organism: | MOUSE |
Description: | 5-HT6 HTR6 MOUSE::Q9R1C8 |
Residue: | 440 |
Sequence: | MVPEPGPVNSSTPAWGPGPPPAPGGSGWVAAALCVVIVLTAAANSLLIALICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTAPRALALILGAWSLAALASFLPLLLGWHELGKARTSAPGQC
RLLASLPYVLVASGVTFFLPSGAICFTYCRILLAARKQAVQVASLTTGTATAGQALETLQ
VPRTPRPGMESADSRRLTTKHSRKALKASLTLGILLSMFFVTWLPFFVASIAQAVCDCIS
PGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFVPCVHCPPEHRASPASPSMWTSHS
GARPGLSLQQVLPLPLPPNSDSDSASGGTSGLQLTAQLLLPGEATRDPPPPTRAPTVVNF
FVTDSVEPEIRQHPLGSPMN
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BDBM78940 |
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n/a |
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Name | BDBM78940 |
Synonyms: | METHIOTHEPIN | MLS000859918 | Methiothepin mesylate salt | SMR000326779 | cid_3039995 | mesylic acid;1-methyl-4-[3-(methylthio)-5,6-dihydrobenzo[b][1]benzothiepin-5-yl]piperazine | methanesulfonic acid;1-methyl-4-(3-methylsulfanyl-5,6-dihydrobenzo[b][1]benzothiepin-5-yl)piperazine | methanesulfonic acid;1-methyl-4-[3-(methylthio)-5,6-dihydrobenzo[b][1]benzothiepin-5-yl]piperazine |
Type | Small organic molecule |
Emp. Form. | C20H24N2S2 |
Mol. Mass. | 356.548 |
SMILES | CSc1ccc2Sc3ccccc3CC(N3CCN(C)CC3)c2c1 |
Structure |
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