Reaction Details |
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Target | 5-hydroxytryptamine receptor 6 |
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Ligand | BDBM50130268 |
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Substrate/Competitor | n/a |
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Ki | 61.66±n/a nM |
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Comments | PDSP_3218 |
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Citation | Hirst, WD; Abrahamsen, B; Blaney, FE; Calver, AR; Aloj, L; Price, GW; Medhurst, AD Differences in the central nervous system distribution and pharmacology of the mouse 5-hydroxytryptamine-6 receptor compared with rat and human receptors investigated by radioligand binding, site-directed mutagenesis, and molecular modeling. Mol Pharmacol64:1295-308 (2003) [PubMed] Article |
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More Info.: | Get all data from this article |
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5-hydroxytryptamine receptor 6 |
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Name: | 5-hydroxytryptamine receptor 6 |
Synonyms: | 5-HT6 | 5-hydroxytryptamine receptor 6 | 5HT6R_MOUSE | Htr6 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 47012.98 |
Organism: | MOUSE |
Description: | 5-HT6 HTR6 MOUSE::Q9R1C8 |
Residue: | 440 |
Sequence: | MVPEPGPVNSSTPAWGPGPPPAPGGSGWVAAALCVVIVLTAAANSLLIALICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTAPRALALILGAWSLAALASFLPLLLGWHELGKARTSAPGQC
RLLASLPYVLVASGVTFFLPSGAICFTYCRILLAARKQAVQVASLTTGTATAGQALETLQ
VPRTPRPGMESADSRRLTTKHSRKALKASLTLGILLSMFFVTWLPFFVASIAQAVCDCIS
PGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFVPCVHCPPEHRASPASPSMWTSHS
GARPGLSLQQVLPLPLPPNSDSDSASGGTSGLQLTAQLLLPGEATRDPPPPTRAPTVVNF
FVTDSVEPEIRQHPLGSPMN
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BDBM50130268 |
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n/a |
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Name | BDBM50130268 |
Synonyms: | CHEMBL329383 | N-(2,5-Dibromo-3-fluoro-phenyl)-4-methoxy-3-piperazin-1-yl-benzenesulfonamide | N-(2,5-dibromo-3-fluorophenyl)-4-methoxy-3-(piperazin-1-yl)benzenesulfonamide | SB-357134 |
Type | Small organic molecule |
Emp. Form. | C17H18Br2FN3O3S |
Mol. Mass. | 523.215 |
SMILES | COc1ccc(cc1N1CCNCC1)S(=O)(=O)Nc1cc(Br)cc(F)c1Br |
Structure |
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