| Reaction Details |
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 | Report a problem with these data |
| Target | Mu-type opioid receptor |
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| Ligand | BDBM86447 |
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| Substrate/Competitor | n/a |
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| Ki | 0.95±n/a nM |
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| Comments | PDSP_4499 |
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| Citation |  Spetea, M; Friedmann, T; Riba, P; Schütz, J; Wunder, G; Langer, T; Schmidhammer, H; Fürst, S In vitro opioid activity profiles of 6-amino acid substituted derivatives of 14-O-methyloxymorphone. Eur J Pharmacol483:301-8 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article |
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| Mu-type opioid receptor |
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| Name: | Mu-type opioid receptor |
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| Synonyms: | MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 44503.11 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor. |
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| Residue: | 398 |
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| Sequence: | MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQT
GSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST
LPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRT
PRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFA
FIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYV
IIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQ
QNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
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| BDBM86447 |
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| n/a |
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| Name | BDBM86447 |
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| Synonyms: | (2S)-2-[(4,5alpha-epoxy-3-hydroxy-14beta-methoxy-17-methylmorphinan-6alpha-yl)amino]-3-phenylpropanoic acid bis(tetrafluroborate) |
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| Type | Small organic molecule |
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| Emp. Form. | C27H32N2O5 |
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| Mol. Mass. | 464.5534 |
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| SMILES | COC12CC[C@H](N[C@H](Cc3ccccc3)C(O)=O)[C@@H]3Oc4c5c(CC1N(C)CC[C@@]235)ccc4O |r,THB:30:22:2:25.28.27,20:21:2:25.28.27| |
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| Structure | 
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