| Reaction Details |
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 | Report a problem with these data |
| Target | D(1A) dopamine receptor |
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| Ligand | BDBM50117182 |
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| Substrate/Competitor | n/a |
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| Ki | 67±n/a nM |
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| Comments | PDSP_4939 |
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| Citation |  Sit, SY; Xie, K; Jacutin-Porte, S; Boy, KM; Seanz, J; Taber, MT; Gulwadi, AG; Korpinen, CD; Burris, KD; Molski, TF; Ryan, E; Xu, C; Verdoorn, T; Johnson, G; Nichols, DE; Mailman, RB Synthesis and SAR exploration of dinapsoline analogues. Bioorg Med Chem12:715-34 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article |
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| D(1A) dopamine receptor |
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| Name: | D(1A) dopamine receptor |
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| Synonyms: | DOPAMINE D1 | DRD1_RAT | Dopamine D1 high | Dopamine D1 low | Dopamine receptor | Dopamine receptor D1 | Dopamine1-like | Drd1 | Drd1a |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 49429.75 |
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| Organism: | RAT |
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| Description: | P18901 |
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| Residue: | 446 |
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| Sequence: | MAPNTSTMDEAGLPAERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNF
FVISLAVSDLLVAVLVMPWKAVAEIAGFWPLGPFCNIWVAFDIMCSTASILNLCVISVDR
YWAISSPFQYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTWPLDGNFTSLED
TEDDNCDTRLSRTYAISSSLISFYIPVAIMIVTYTSIYRIAQKQIRRISALERAAVHAKN
CQTTAGNGNPVECAQSESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFISNCMVPFCGS
EETQPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFQKAFSTLLGCYRLCPTTNNAIET
VSINNNGAVVFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKKEEAGGIAKPLEKLSPAL
SVILDYDTDVSLEKIQPVTHSGQHST
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| BDBM50117182 |
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| n/a |
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| Name | BDBM50117182 |
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| Synonyms: | 2,3,7,11b-Tetrahydro-1H-dibenzo[de,h]isoquinoline-8,9-diol | CHEMBL120995 | Dinapsoline, (+/-) |
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| Type | Small organic molecule |
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| Emp. Form. | C16H15NO2 |
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| Mol. Mass. | 253.2958 |
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| SMILES | Oc1ccc2C3CNCc4cccc(Cc2c1O)c34 |
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| Structure | 
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