| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Hrh3 protein |
|---|
| Ligand | BDBM50240709 |
|---|
| Substrate/Competitor | n/a |
|---|
| Ki | 6.28±n/a nM |
|---|
| Comments | PDSP_3767 |
|---|
| Citation |  Hancock, AA; Bennani, YL; Bush, EN; Esbenshade, TA; Faghih, R; Fox, GB; Jacobson, P; Knourek-Segel, V; Krueger, KM; Nuss, ME; Pan, JB; Shapiro, R; Witte, DG; Yao, BB Antiobesity effects of A-331440, a novel non-imidazole histamine H3 receptor antagonist. Eur J Pharmacol487:183-97 (2004) [PubMed] Article |
|---|
| More Info.: | Get all data from this article |
|---|
| |
| Hrh3 protein |
|---|
| Name: | Hrh3 protein |
|---|
| Synonyms: | HISTAMINE H3 | HRH3 | Hrh3 protein |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 37860.96 |
|---|
| Organism: | RAT |
|---|
| Description: | Q5PPG3 |
|---|
| Residue: | 344 |
|---|
| Sequence: | MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCAS
SVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAG
PEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRGSKPSASSASLEKRMKMVSQSITQRF
RLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDY
|
|
|
|---|
| BDBM50240709 |
|---|
| n/a |
|---|
| Name | BDBM50240709 |
|---|
| Synonyms: | (R)-4'-(3-(3-(dimethylamino)pyrrolidin-1-yl)propoxy)biphenyl-4-carbonitrile | 4'-[3-((R)-3-Dimethylamino-pyrrolidin-1-yl)-propoxy]-biphenyl-4-carbonitrile | A-331440 | CHEMBL319000 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H27N3O |
|---|
| Mol. Mass. | 349.4693 |
|---|
| SMILES | CN(C)[C@@H]1CCN(CCCOc2ccc(cc2)-c2ccc(cc2)C#N)C1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
