| Reaction Details |
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 | Report a problem with these data |
| Target | Neuronal acetylcholine receptor subunit alpha-5 |
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| Ligand | BDBM86543 |
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| Substrate/Competitor | n/a |
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| Ki | 1290±n/a nM |
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| Comments | PDSP_4101 |
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| Citation |  Grinevich, VP; Letchworth, SR; Lindenberger, KA; Menager, J; Mary, V; Sadieva, KA; Buhlman, LM; Bohme, GA; Pradier, L; Benavides, J; Lukas, RJ; Bencherif, M Heterologous expression of human {alpha}6{beta}4{beta}3{alpha}5 nicotinic acetylcholine receptors: binding properties consistent with their natural expression require quaternary subunit assembly including the {alpha}5 subunit. J Pharmacol Exp Ther312:619-26 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article |
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| Neuronal acetylcholine receptor subunit alpha-5 |
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| Name: | Neuronal acetylcholine receptor subunit alpha-5 |
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| Synonyms: | ACHA5_RAT | Acra5 | Cholinergic, Nicotinic Alpha6Beta3Beta4Alpha5 | Chrna5 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 51875.01 |
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| Organism: | RAT |
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| Description: | Cholinergic, Nicotinic Alpha6Beta3Beta4Alpha5 0 RAT::P20420 |
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| Residue: | 452 |
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| Sequence: | MVQLLAGRWRPTGARRGTRGGLPELSSAAKHEDSLFRDLFEDYERWVRPVEHLSDKIKIK
FGLAISQLVDVDEKNQLMTTNVWLKQEWIDVKLRWNPDDYGGIKIIRVPSDSLWIPDIVL
FDNADGRFEGASTKTVVRYNGTVTWTQPANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDG
SQVDIILEDQDVDRTDFFDNGEWEIMSAMGSKGNRTDSCCWYPYITYSFVIKRLPLFYTL
FLIIPCIGLSFLTVVVFYLPSNEGEKISLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGE
YLVFTMIFVTLSIMVTVFAINIHHRSSSTHNAMAPWVRKIFLHKLPKLLCMRSHADRYFT
QREEAESGAGPKSRNTLEAALDCIRYITRHVVKENDVREVVEDWKFIAQVLDRMFLWTFL
LVSIIGTLGLFVPVIYKWANIIVPVHIGNTIK
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| BDBM86543 |
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| n/a |
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| Name | BDBM86543 |
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| Synonyms: | CAS_156223-05-1 | GTS-21 | NSC_122225 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H20N2O2 |
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| Mol. Mass. | 308.3743 |
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| SMILES | COc1ccc(C=C2CCCN=C2c2cccnc2)c(OC)c1 |w:6.5,c:11| |
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| Structure | 
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