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TargetNeuronal acetylcholine receptor subunit alpha-5
LigandBDBM50079456
Substrate/Competitorn/a
Ki 1.75±n/a nM
CommentsPDSP_4099
Citation Grinevich, VPLetchworth, SRLindenberger, KAMenager, JMary, VSadieva, KABuhlman, LMBohme, GAPradier, LBenavides, JLukas, RJBencherif, M Heterologous expression of human {alpha}6{beta}4{beta}3{alpha}5 nicotinic acetylcholine receptors: binding properties consistent with their natural expression require quaternary subunit assembly including the {alpha}5 subunit. J Pharmacol Exp Ther312:619-26 (2005) [PubMed]  Article
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Neuronal acetylcholine receptor subunit alpha-5
Name:Neuronal acetylcholine receptor subunit alpha-5
Synonyms:ACHA5_RAT | Acra5 | Cholinergic, Nicotinic Alpha6Beta3Beta4Alpha5 | Chrna5
Type:Enzyme Catalytic Domain
Mol. Mass.:51875.01
Organism:RAT
Description:Cholinergic, Nicotinic Alpha6Beta3Beta4Alpha5 0 RAT::P20420
Residue:452
Sequence:
MVQLLAGRWRPTGARRGTRGGLPELSSAAKHEDSLFRDLFEDYERWVRPVEHLSDKIKIK
FGLAISQLVDVDEKNQLMTTNVWLKQEWIDVKLRWNPDDYGGIKIIRVPSDSLWIPDIVL
FDNADGRFEGASTKTVVRYNGTVTWTQPANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDG
SQVDIILEDQDVDRTDFFDNGEWEIMSAMGSKGNRTDSCCWYPYITYSFVIKRLPLFYTL
FLIIPCIGLSFLTVVVFYLPSNEGEKISLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGE
YLVFTMIFVTLSIMVTVFAINIHHRSSSTHNAMAPWVRKIFLHKLPKLLCMRSHADRYFT
QREEAESGAGPKSRNTLEAALDCIRYITRHVVKENDVREVVEDWKFIAQVLDRMFLWTFL
LVSIIGTLGLFVPVIYKWANIIVPVHIGNTIK
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  Blast E-value cutoff:
BDBM50079456
n/a
NameBDBM50079456
Synonyms:2-Pyridin-3-yl-1-aza-bicyclo[2.2.2]octane | CHEMBL105374 | TC-2429
TypeSmall organic molecule
Emp. Form.C12H16N2
Mol. Mass.188.2688
SMILESC1CN2CCC1CC2c1cccnc1 |(15.84,-6.24,;14.49,-7,;16.04,-8.15,;16.81,-6.8,;16.04,-5.47,;14.49,-5.47,;13.72,-6.8,;14.49,-8.15,;13.17,-8.93,;11.82,-8.15,;10.5,-8.95,;10.5,-10.47,;11.82,-11.27,;13.17,-10.47,)|
Structure
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