| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H2 receptor |
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| Ligand | BDBM50159110 |
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| Substrate/Competitor | n/a |
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| Ki | >10000±n/a nM |
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| Comments | PDSP_3762 |
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| Citation |  Barbier, AJ; Berridge, C; Dugovic, C; Laposky, AD; Wilson, SJ; Boggs, J; Aluisio, L; Lord, B; Mazur, C; Pudiak, CM; Langlois, X; Xiao, W; Apodaca, R; Carruthers, NI; Lovenberg, TW Acute wake-promoting actions of JNJ-5207852, a novel, diamine-based H3 antagonist. Br J Pharmacol143:649-61 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article |
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| Histamine H2 receptor |
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| Name: | Histamine H2 receptor |
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| Synonyms: | Gastric receptor I | H2R | HISTAMINE H2 | HRH2 | HRH2_HUMAN | Histamine H2 receptor | Histamine H2-Gs alpha S |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 40115.31 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 359 |
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| Sequence: | MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSL
AITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV
MDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNE
VYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVM
GAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQ
QLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDR
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| BDBM50159110 |
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| n/a |
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| Name | BDBM50159110 |
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| Synonyms: | 1-(3-(4-(piperidin-1-ylmethyl)phenoxy)propyl)piperidine | 1-(4-(3-(piperidin-1-yl)propoxy)benzyl)piperidine | 1-[3-(4-hexahydro-1-pyridinylmethylphenoxy)propyl]hexahydropyridine | 1-[4-(3-hexahydro-1-pyridinylpropoxy)benzyl]hexahydropyridine | CHEMBL129542 | JNJ-5207852 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H32N2O |
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| Mol. Mass. | 316.4809 |
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| SMILES | C(COc1ccc(CN2CCCCC2)cc1)CN1CCCCC1 |
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| Structure | 
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