Reaction Details |
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Target | Aurora kinase C |
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Ligand | BDBM86598 |
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Substrate/Competitor | n/a |
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Meas. Tech. | In Vitro Kinase Assay |
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IC50 | 40.5±0.0 nM |
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Citation | Kwiatkowski, N; Deng, X; Wang, J; Tan, L; Villa, F; Santaguida, S; Huang, HC; Mitchison, T; Musacchio, A; Gray, N Selective aurora kinase inhibitors identified using a taxol-induced checkpoint sensitivity screen. ACS Chem Biol7:185-96 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Aurora kinase C |
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Name: | Aurora kinase C |
Synonyms: | AIE2 | AIK3 | AIRK3 | ARK3 | AURKC | AURKC_HUMAN | Aurora Kinase C (Aurora-C) | Aurora kinase C | Aurora kinase C (AURKC) | Aurora-C | Aurora-C/INCENP | Aurora/Ipl1-related kinase 3 | Aurora/Ipl1/Eg2 protein 2 | STK13 | Serine/threonine-protein kinase 13 | Serine/threonine-protein kinase Aurora-C |
Type: | Enzyme |
Mol. Mass.: | 35602.43 |
Organism: | Homo sapiens (Human) |
Description: | Amino acid residues 1-309 were expressed as His-tagged fusion protein using baculovirus expression system. |
Residue: | 309 |
Sequence: | MSSPRAVVQLGKAQPAGEELATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLA
RLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLIL
EYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEV
KIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFE
SASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRRV
LPPCAQMAS
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BDBM86598 |
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n/a |
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Name | BDBM86598 |
Synonyms: | Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one, 3 |
Type | Small organic molecule |
Emp. Form. | C24H27N7O |
Mol. Mass. | 429.5175 |
SMILES | CN1CCN(CC1)c1ccc(Nc2ncc3N(C)C(=O)c4ccccc4N(C)c3n2)cc1 |
Structure |
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