Ki Summary

Reaction Details

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Target

Nociceptin receptor

Ligand

BDBM85822

Substrate/Competitor

n/a

11.48±n/a nM

Comments

PDSP_1267

Citation

Carr&aagrovr;, G; Rizzi, A; Guerrini, R; Barnes, TA; McDonald, J; Hebbes, CP; Mela, F; Kenigs, VA; Marzola, G; Rizzi, D; Gavioli, E; Zucchini, S; Regoli, D; Morari, M; Salvadori, S; Rowbotham, DJ; Lambert, DG; Kapusta, DR; Calo', G [(pF)Phe4,Arg14,Lys15]N/OFQ-NH2 (UFP-102), a highly potent and selective agonist of the nociceptin/orphanin FQ receptor. J Pharmacol Exp Ther312:1114-23 (2005) [PubMed] Article

More Info.:

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Nociceptin receptor

Name:

Nociceptin receptor

Synonyms:

Nociceptin/Orphanin FQ, NOP receptor | OPRL1 | OPRX_PIG

Type:

Enzyme Catalytic Domain

Mol. Mass.:

40620.31

Organism:

GUINEA PIG

Description:

Nociceptin/Orphanin FQ, NOP receptor 0 GUINEA PIG::P79292

Residue:

370

Sequence:

MESLFPAPFWEVLYGSPLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLA
VCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTAVLLTLPFQGTDVLLGFWPFGN
ALCKAVIAIDYYNMFTSAFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASI
VGVPVAIMGSAQVEDEEIECLVEIPAPQDYWGPVFAVCIFLFSFVIPVLIISVCYSLMVR
RLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLVQGLGVQPGSETAVAV
LRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCAPTRRREMQVSDRVRSIAKDVALAC
KTSETVPRPA

BDBM85822

n/a

Name

BDBM85822

Synonyms:

Demethyl-AMPA | OFQ/N | OFQ/N (1-11) | OFQ/N (1-11),[Tyr10]

Type

Small organic molecule

Emp. Form.

C61H100N22O15

Mol. Mass.

1381.5851

SMILES

[#6]-[#6@@H](-[#8])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](-[#7])=O

Structure