Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetDelta-type opioid receptor
LigandBDBM86667
Substrate/Competitorn/a
Ki 0.11±n/a nM
CommentsPDSP_4768
Citation Tryoen-Tóth PDécaillot FMFilliol DBefort KLazarus LHSchiller PWSchmidhammer HKieffer BL Inverse agonism and neutral antagonism at wild-type and constitutively active mutant delta opioid receptors. J Pharmacol Exp Ther 313:410-21 (2005) [PubMed]  Article
More Info.:Get all data from this article
 
Delta-type opioid receptor
Name:Delta-type opioid receptor
Synonyms:D-OR-1 | DOR-1 | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRK1 | opioid receptor, delta 1
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:40382.98
Organism:Homo sapiens (Human)
Description:Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM86667
n/a
NameBDBM86667
Synonyms:HS464
TypeSmall organic molecule
Emp. Form.C28H29N2O3
Mol. Mass.441.5415
SMILESCCO[C@]12Cc3c(nc4ccccc34)C3Oc4c5c(CC1N(CC1CC1)CCC235)ccc4O |r,TLB:22:21:18.19.17:3,16:17:3:21.26.27,THB:2:3:18.19.17:21.26.27|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: