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TargetDelta-type opioid receptor
LigandBDBM86665
Substrate/Competitorn/a
Ki 0.42±n/a nM
CommentsPDSP_4770
Citation Tryoen-Tóth, PDécaillot, FMFilliol, DBefort, KLazarus, LHSchiller, PWSchmidhammer, HKieffer, BL Inverse agonism and neutral antagonism at wild-type and constitutively active mutant delta opioid receptors. J Pharmacol Exp Ther313:410-21 (2005) [PubMed]  Article
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Delta-type opioid receptor
Name:Delta-type opioid receptor
Synonyms:D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:40382.98
Organism:Homo sapiens (Human)
Description:Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA
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BDBM86665
n/a
NameBDBM86665
Synonyms:HS531
TypeSmall organic molecule
Emp. Form.C27H28N2O3
Mol. Mass.428.5228
SMILESCO[C@]12Cc3c(C4Oc5c6c(CC1N(CC=C)CCC246)ccc5O)n(C)c1ccccc31 |r,TLB:14:13:10.11.9:2,8:9:2:13.17.18,THB:1:2:10.11.9:13.17.18|
Structure
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