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TargetHistamine receptor H3
LigandBDBM50158595
Substrate/Competitorn/a
Ki 1.20±n/a nM
CommentsPDSP_4080
Citation Esbenshade, TAFox, GBKrueger, KMMiller, TRKang, CHDenny, LIWitte, DGYao, BBPan, LWetter, JMarsh, KBennani, YLCowart, MDSullivan, JPHancock, AA Pharmacological properties of ABT-239 [4-(2-{2-[(2R)-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: I. Potent and selective histamine H3 receptor antagonist with drug-like properties. J Pharmacol Exp Ther313:165-75 (2005) [PubMed]  Article
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Histamine receptor H3
Name:Histamine receptor H3
Synonyms:HISTAMINE H3 | HRH3
Type:Enzyme Catalytic Domain
Mol. Mass.:16901.59
Organism:Dog
Description:Q865E3
Residue:147
Sequence:
FLLNLAISDFLVGAFCIPLYVPYVLTGRWPFSRGLCKLWLVVDYLLCTSSVFNIVLISYD
RFLSVTRAVSYRAQQGDTRRAVQKMVLVWVLAFLLYGPAILSWEHLSGGSSIPEGHCYAE
FFYNWYFLITASTLEFFTPFLSVTFFN
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BDBM50158595
n/a
NameBDBM50158595
Synonyms:(4'-(3-((2R,5R)-2,5-dimethylpyrrolidin-1-yl)propoxy)biphenyl-4-yl)(morpholino)methanone | A-349821 | CHEMBL179702 | {4''-[3-((2R,5R)-2,5-Dimethyl-pyrrolidin-1-yl)-propoxy]-biphenyl-4-yl}-morpholin-4-yl-methanone | {4'-[3-((2R,5R)-2,5-Dimethyl-pyrrolidin-1-yl)-propoxy]-biphenyl-4-yl}-morpholin-4-yl-methanone
TypeSmall organic molecule
Emp. Form.C26H34N2O3
Mol. Mass.422.5598
SMILESC[C@@H]1CC[C@@H](C)N1CCCOc1ccc(cc1)-c1ccc(cc1)C(=O)N1CCOCC1 |r|
Structure
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