Reaction Details |
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Target | Histamine receptor H3 |
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Ligand | BDBM50158595 |
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Substrate/Competitor | n/a |
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Ki | 1.20±n/a nM |
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Comments | PDSP_4080 |
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Citation | Esbenshade, TA; Fox, GB; Krueger, KM; Miller, TR; Kang, CH; Denny, LI; Witte, DG; Yao, BB; Pan, L; Wetter, J; Marsh, K; Bennani, YL; Cowart, MD; Sullivan, JP; Hancock, AA Pharmacological properties of ABT-239 [4-(2-{2-[(2R)-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: I. Potent and selective histamine H3 receptor antagonist with drug-like properties. J Pharmacol Exp Ther313:165-75 (2005) [PubMed] Article |
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More Info.: | Get all data from this article |
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Histamine receptor H3 |
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Name: | Histamine receptor H3 |
Synonyms: | HISTAMINE H3 | HRH3 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 16901.59 |
Organism: | Dog |
Description: | Q865E3 |
Residue: | 147 |
Sequence: | FLLNLAISDFLVGAFCIPLYVPYVLTGRWPFSRGLCKLWLVVDYLLCTSSVFNIVLISYD
RFLSVTRAVSYRAQQGDTRRAVQKMVLVWVLAFLLYGPAILSWEHLSGGSSIPEGHCYAE
FFYNWYFLITASTLEFFTPFLSVTFFN
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BDBM50158595 |
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n/a |
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Name | BDBM50158595 |
Synonyms: | (4'-(3-((2R,5R)-2,5-dimethylpyrrolidin-1-yl)propoxy)biphenyl-4-yl)(morpholino)methanone | A-349821 | CHEMBL179702 | {4''-[3-((2R,5R)-2,5-Dimethyl-pyrrolidin-1-yl)-propoxy]-biphenyl-4-yl}-morpholin-4-yl-methanone | {4'-[3-((2R,5R)-2,5-Dimethyl-pyrrolidin-1-yl)-propoxy]-biphenyl-4-yl}-morpholin-4-yl-methanone |
Type | Small organic molecule |
Emp. Form. | C26H34N2O3 |
Mol. Mass. | 422.5598 |
SMILES | C[C@@H]1CC[C@@H](C)N1CCCOc1ccc(cc1)-c1ccc(cc1)C(=O)N1CCOCC1 |r| |
Structure |
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