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TargetNociceptin receptor
LigandBDBM86695
Substrate/Competitorn/a
Ki 0.50±n/a nM
CommentsPDSP_4219
Citation Kapusta, DRThorkildsen, CKenigs, VAMeier, EVinge, MMQuist, CPetersen, JS Pharmacodynamic characterization of ZP120 (Ac-RYYRWKKKKKKK-NH2), a novel, functionally selective nociceptin/orphanin FQ peptide receptor partial agonist with sodium-potassium-sparing aquaretic activity. J Pharmacol Exp Ther314:652-60 (2005) [PubMed]  Article
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Nociceptin receptor
Name:Nociceptin receptor
Synonyms:KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:40702.87
Organism:Homo sapiens (Human)
Description:P41146
Residue:370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLA
VCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGN
ALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASV
VGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIR
RLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAI
LRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALAC
KTSETVPRPA
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BDBM86695
n/a
NameBDBM86695
Synonyms:Ac-RYYRWKKKKKKK-NH2 | ZP120
TypeSmall organic molecule
Emp. Form.C84H141N28O15
Mol. Mass.1783.1964
SMILESCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)[N+](=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O |r,wU:50.51,4.3,91.94,27.27,73.76,109.112,wD:100.109,82.85,64.67,39.40,15.14,118.121,(-12.32,.46,;-10.99,1.23,;-10.99,2.77,;-9.65,.46,;-8.36,1.24,;-8.36,2.78,;-9.69,3.55,;-9.69,5.09,;-11.02,5.86,;-11.02,7.4,;-12.36,8.17,;-9.69,8.17,;-7.02,.47,;-7.02,-1.07,;-5.69,1.24,;-4.35,.47,;-4.35,-1.07,;-3.02,-1.84,;-3.02,-3.38,;-1.68,-4.15,;-.35,-3.38,;.98,-4.15,;-.35,-1.84,;-1.68,-1.07,;-3.01,1.24,;-3.01,2.78,;-1.68,.47,;-.36,1.26,;-.36,2.8,;.73,3.89,;.73,5.43,;2.07,6.2,;3.4,5.43,;4.73,6.2,;3.4,3.89,;2.07,3.12,;.98,.49,;.98,-1.05,;2.32,1.26,;3.65,.49,;3.65,-1.05,;4.99,-1.82,;4.99,-3.36,;6.32,-4.13,;6.32,-5.67,;7.65,-6.44,;5.23,-6.76,;4.99,1.26,;4.99,2.8,;6.32,.49,;7.65,1.26,;7.65,2.8,;8.99,3.57,;10.47,3.17,;11.31,4.46,;10.34,5.66,;10.58,7.18,;9.39,8.15,;7.95,7.6,;7.71,6.08,;8.91,5.11,;8.99,.49,;8.99,-1.05,;10.33,1.24,;11.66,.47,;11.66,-1.07,;13,-1.84,;13,-3.38,;14.33,-4.15,;14.33,-5.69,;13,1.24,;13,2.78,;14.33,.47,;15.66,1.25,;15.66,2.79,;16.99,3.56,;16.99,5.1,;18.32,5.87,;18.35,7.41,;16.99,.48,;16.99,-1.06,;18.34,1.23,;19.67,.46,;19.67,-1.08,;21,-1.85,;21,-3.39,;22.34,-4.16,;22.34,-5.7,;21.01,1.23,;21.01,2.77,;22.34,.46,;23.66,1.25,;23.66,2.79,;25,3.56,;25,5.1,;26.33,5.87,;26.35,7.4,;25,.48,;25,-1.06,;26.34,1.24,;27.68,.47,;27.68,-1.07,;29.01,-1.84,;29.01,-3.38,;30.34,-4.15,;30.34,-5.69,;29.01,1.24,;29.01,2.78,;30.34,.46,;31.67,1.25,;31.67,2.79,;33.01,3.56,;33.01,5.1,;34.34,5.87,;34.36,7.4,;33,.48,;33,-1.06,;34.34,1.24,;35.67,.47,;35.67,-1.07,;37,-1.84,;37,-3.38,;38.34,-4.15,;38.34,-5.69,;37.01,1.24,;38.34,.47,;37.01,2.78,)|
Structure
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