| Reaction Details |
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 | Report a problem with these data |
| Target | Metabotropic glutamate receptor 5 |
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| Ligand | BDBM86716 |
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| Substrate/Competitor | n/a |
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| Ki | 40.8±n/a nM |
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| Comments | PDSP_4884 |
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| Citation |  Porter, RH; Jaeschke, G; Spooren, W; Ballard, TM; Büttelmann, B; Kolczewski, S; Peters, JU; Prinssen, E; Wichmann, J; Vieira, E; Mühlemann, A; Gatti, S; Mutel, V; Malherbe, P Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity. J Pharmacol Exp Ther315:711-21 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article |
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| Metabotropic glutamate receptor 5 |
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| Name: | Metabotropic glutamate receptor 5 |
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| Synonyms: | GPRC1E | GRM5 | GRM5_HUMAN | MGLUR5 | metabotropic glutamate 5 | metabotropic glutamate 5a |
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| Type: | Enzyme |
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| Mol. Mass.: | 132484.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 1212 |
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| Sequence: | MVLLLILSVLLLKEDVRGSAQSSERRVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAV
REQYGIQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHSAVALEQSIEFIRDSLISS
EEEEGLVRCVDGSSSSFRSKKPIVGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLS
DKTLFKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEGI
CIAHSYKIYSNAGEQSFDKLLKKLTSHLPKARVVACFCEGMTVRGLLMAMRRLGLAGEFL
LLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLKLRPETNHRNPWFQEFWQ
HRFQCRLEGFPQENSKYNKTCNSSLTLKTHHVQDSKMGFVINAIYSMAYGLHNMQMSLCP
GYAGLCDAMKPIDGRKLLESLMKTNFTGVSGDTILFDENGDSPGRYEIMNFKEMGKDYFD
YINVGSWDNGELKMDDDEVWSKKSNIIRSVCSEPCEKGQIKVIRKGEVSCCWTCTPCKEN
EYVFDEYTCKACQLGSWPTDDLTGCDLIPVQYLRWGDPEPIAAVVFACLGLLATLFVTVV
FIIYRDTPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAMSYS
ALVTKTNRIARILAGSKKKICTKKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPDIM
HDYPSIREVYLICNTTNLGVVTPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYT
TCIIWLAFVPIYFGSNYKIITMCFSVSLSATVALGCMFVPKVYIILAKPERNVRSAFTTS
TVVRMHVGDGKSSSAASRSSSLVNLWKRRGSSGETLRYKDRRLAQHKSEIECFTPKGSMG
NGGRATMSSSNGKSVTWAQNEKSSRGQHLWQRLSIHINKKENPNQTAVIKPFPKSTESRG
LGAGAGAGGSAGGVGATGGAGCAGAGPGGPESPDAGPKALYDVAEAEEHFPAPARPRSPS
PISTLSHRAGSASRTDDDVPSLHSEPVARSSSSQGSLMEQISSVVTRFTANISELNSMML
STAAPSPGVGAPLCSSYLIPKEIQLPTTMTTFAEIQPLPAIEVTGGAQPAAGAQAAGDAA
RESPAAGPEAAAAKPDLEELVALTPPSPFRDSVDSGSTTPNSPVSESALCIPSSPKYDTL
IIRDYTQSSSSL
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| BDBM86716 |
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| n/a |
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| Name | BDBM86716 |
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| Synonyms: | CAS_63540-28-3 | CHEMBL239800 | Fenobam | NSC_216215 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H11ClN4O2 |
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| Mol. Mass. | 266.684 |
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| SMILES | Cn1cc(O)nc1NC(=O)Nc1cccc(Cl)c1 |
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| Structure | 
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