| Reaction Details |
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 | Report a problem with these data |
| Target | Potassium voltage-gated channel subfamily H member 2 |
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| Ligand | BDBM86757 |
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| Substrate/Competitor | n/a |
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| Ki | >10000±n/a nM |
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| Comments | PDSP_7627 |
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| Citation |  Kumar, JS; Prabhakaran, J; Majo, VJ; Milak, MS; Hsiung, SC; Tamir, H; Simpson, NR; Van Heertum, RL; Mann, JJ; Parsey, RV Synthesis and in vivo evaluation of a novel 5-HT1A receptor agonist radioligand [O-methyl- 11C]2-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)-4-methyl-1,2,4-triazine-3,5(2H,4H)dione in nonhuman primates. Eur J Nucl Med Mol Imaging34:1050-60 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article |
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| Potassium voltage-gated channel subfamily H member 2 |
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| Name: | Potassium voltage-gated channel subfamily H member 2 |
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| Synonyms: | HERG | KCNH2 protein |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 92746.99 |
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| Organism: | BOVINE |
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| Description: | A5PKI1 |
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| Residue: | 849 |
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| Sequence: | MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVM
QRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDG
AVIMFILNFEVVMEKGLVGSPARDTNHRAPPTSWLAAGRAKTFRLKLPALLALTARASSV
RPGSAGGAGAPGAVVVDVDLTPAAPSSESLALDEVTAMDNHVAGRAAEERRALVGPGSPP
PPPPPPPLPACVPGPHPSPRAHSLNPDASGSSCSLARTRSRESCASVRRASSADDIEAMR
TGALPPPPPRHASTGAMHPLRSGLLNSTSDSDLVRYRTISKIPQITLNFVDLKGDPFLAS
PTSDREIIAPKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWD
WLILLLVIYTAVFTPYSAAFLLKETEEAPLAPDCGYACQPLAVVDLIVDIMFIVDILINF
RTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLR
LVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGD
QIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLM
YASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGI
DMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVH
AGDLLTALYFISRGSIEILRGDVVVAILGTAGTGSWARSPCRSCRGPALEGHSPGGCGPV
TAHRGLGLL
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| BDBM86757 |
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| n/a |
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| Name | BDBM86757 |
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| Synonyms: | CAS_0 | NSC_11603174 | [11C]MMP |
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| Type | Small organic molecule |
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| Emp. Form. | C19H27N5O3 |
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| Mol. Mass. | 373.4494 |
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| SMILES | COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1 |
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| Structure | 
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