Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetGlutaminase kidney isoform, mitochondrial
LigandBDBM278407
Substrate/Competitorn/a
Meas. Tech.GLS Enzyme Potency Assay
pH7.8±n/a
IC50 85.1±n/a nM
Commentsextracted
Citation Finlay, MREkwuru, CTCharles, MDRaubo, PAWinter, JJNissink, JW 1,3,4-thiadiazole compounds and their use in treating cancer US Patent US10040788 Publication Date 8/7/2018
More Info.:Get all data from this article,  Assay Method
 
Glutaminase kidney isoform, mitochondrial
Name:Glutaminase kidney isoform, mitochondrial
Synonyms:GLS | GLS1 | GLSK_HUMAN | Glutaminase 1 | K-glutaminase | KIAA0838 | L-glutamine amidohydrolase
Type:Protein
Mol. Mass.:73471.89
Organism:Homo sapiens (Human)
Description:O94925
Residue:669
Sequence:
MMRLRGSGMLRDLLLRSPAGVSATLRRAQPLVTLCRRPRGGGRPAAGPAAAARLHPWWGG
GGWPAEPLARGLSSSPSEILQELGKGSTHPQPGVSPPAAPAAPGPKDGPGETDAFGNSEG
KELVASGENKIKQGLLPSLEDLLFYTIAEGQEKIPVHKFITALKSTGLRTSDPRLKECMD
MLRLTLQTTSDGVMLDKDLFKKCVQSNIVLLTQAFRRKFVIPDFMSFTSHIDELYESAKK
QSGGKVADYIPQLAKFSPDLWGVSVCTVDGQRHSTGDTKVPFCLQSCVKPLKYAIAVNDL
GTEYVHRYVGKEPSGLRFNKLFLNEDDKPHNPMVNAGAIVVTSLIKQGVNNAEKFDYVMQ
FLNKMAGNEYVGFSNATFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYFQLCSI
EVTCESASVMAATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDFSGQFAFHVGLPA
KSGVAGGILLVVPNVMGMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHFAKKL
DPRREGGDQRVKSVINLLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGHVE
VVKFLLEACKVNPFPKDRWNNTPMDEALHFGHHDVFKILQEYQVQYTPQGDSDNGKENQT
VHKNLDGLL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM278407
n/a
NameBDBM278407
Synonyms:(2S)-2-[3-(Difluoromethoxy)phenyl]-2-methoxy-N-[5-[[(3R)-1-(1,2,4-triazin-3-yl)pyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]acetamide | BDBM278428 | US10040788, Example 6(a) | US10294221, Example 19(b)
TypeSmall organic molecule
Emp. Form.C19H20F2N8O3S
Mol. Mass.478.476
SMILESCO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1cccc(OC(F)F)c1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: