| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Glutaminase kidney isoform, mitochondrial |
|---|
| Ligand | BDBM278400 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | GLS Enzyme Potency Assay |
|---|
| pH | 7.8±n/a |
|---|
| IC50 | 16.2±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Finlay, MR; Ekwuru, CT; Charles, MD; Raubo, PA; Winter, JJ; Nissink, JW 1,3,4-thiadiazole compounds and their use in treating cancer US Patent US10040788 Publication Date 8/7/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Glutaminase kidney isoform, mitochondrial |
|---|
| Name: | Glutaminase kidney isoform, mitochondrial |
|---|
| Synonyms: | GLS | GLS1 | GLSK_HUMAN | Glutaminase 1 | K-glutaminase | KIAA0838 | L-glutamine amidohydrolase |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 73471.89 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O94925 |
|---|
| Residue: | 669 |
|---|
| Sequence: | MMRLRGSGMLRDLLLRSPAGVSATLRRAQPLVTLCRRPRGGGRPAAGPAAAARLHPWWGG
GGWPAEPLARGLSSSPSEILQELGKGSTHPQPGVSPPAAPAAPGPKDGPGETDAFGNSEG
KELVASGENKIKQGLLPSLEDLLFYTIAEGQEKIPVHKFITALKSTGLRTSDPRLKECMD
MLRLTLQTTSDGVMLDKDLFKKCVQSNIVLLTQAFRRKFVIPDFMSFTSHIDELYESAKK
QSGGKVADYIPQLAKFSPDLWGVSVCTVDGQRHSTGDTKVPFCLQSCVKPLKYAIAVNDL
GTEYVHRYVGKEPSGLRFNKLFLNEDDKPHNPMVNAGAIVVTSLIKQGVNNAEKFDYVMQ
FLNKMAGNEYVGFSNATFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYFQLCSI
EVTCESASVMAATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDFSGQFAFHVGLPA
KSGVAGGILLVVPNVMGMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHFAKKL
DPRREGGDQRVKSVINLLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGHVE
VVKFLLEACKVNPFPKDRWNNTPMDEALHFGHHDVFKILQEYQVQYTPQGDSDNGKENQT
VHKNLDGLL
|
|
|
|---|
| BDBM278400 |
|---|
| n/a |
|---|
| Name | BDBM278400 |
|---|
| Synonyms: | (2S)-2-Methoxy-2-phenyl-N-[5-[[(3R)-1-pyridazin-3-ylpyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]acetamide | BDBM278426 | US10040788, Example 2(a) | US10294221, Example 20(b) |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H21N7O2S |
|---|
| Mol. Mass. | 411.481 |
|---|
| SMILES | CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccccc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
