| Reaction Details |
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 | Report a problem with these data |
| Target | Neuronal acetylcholine receptor subunit alpha-4 |
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| Ligand | BDBM86818 |
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| Substrate/Competitor | n/a |
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| Ki | 0.12±n/a nM |
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| Comments | PDSP_8543 |
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| Citation |  Ivy Carroll, F; Yokota, Y; Ma, W; Lee, JR; Brieaddy, LE; Burgess, JP; Navarro, HA; Damaj, MI; Martin, BR Synthesis, nicotinic acetylcholine receptor binding, and pharmacological properties of 3'-(substituted phenyl)deschloroepibatidine analogs. Bioorg Med Chem16:746-54 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article |
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| Neuronal acetylcholine receptor subunit alpha-4 |
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| Name: | Neuronal acetylcholine receptor subunit alpha-4 |
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| Synonyms: | ACHA4_RAT | Acra4 | Cholinergic, Nicotinic Alpha4Beta2 | Cholinergic, Nicotinic Alpha4Beta4 | Chrna4 | Neuronal acetylcholine receptor | Neuronal acetylcholine receptor (alpha4beta2 nAChR) | Neuronal acetylcholine receptor protein alpha-4 subunit | Neuronal acetylcholine receptor subunit alpha 4 beta 2 | Neuronal acetylcholine receptor subunit alpha-4 |
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| Type: | Enzyme |
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| Mol. Mass.: | 70196.44 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P09483 |
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| Residue: | 630 |
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| Sequence: | MANSGTGAPPPLLLLPLLLLLGTGLLPASSHIETRAHAEERLLKRLFSGYNKWSRPVANI
SDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPGDYENVTSIRIPSELI
WRPDIVLYNNADGDFAVTHLTKAHLFYDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMK
FGSWTYDKAKIDLVSMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFI
IRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKVTLCISVLLSLTVFLLLITEIIPS
PTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPAWVRRVFLDIVPRLLF
MKRPSVVKDNCRRLIESMHKMANAPRFWPEPVGEPGILSDICNQGLSPAPTFCNPTDTAV
ETQPTCRSPPLEVPDLKTSEVEKASPCPSPGSCPPPKSSSGAPMLIKARSLSVQHVPSSQ
EAAEDGIRCRSRSIQYCVSQDGAASLADSKPTSSPTSLKARPSQLPVSDQASPCKCTCKE
PSPVSPVTVLKAGGTKAPPQHLPLSPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAM
VIDRIFLWMFIIVCLLGTVGLFLPPWLAAC
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| BDBM86818 |
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| n/a |
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| Name | BDBM86818 |
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| Synonyms: | CAS_45266054 | NSC_45266054 | rac-2-(6-fluoro-5-(3-methoxyphenyl)pyridin-3-yl)-7-aza-bicyclo[2.2.1]heptane hydrochloride |
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| Type | Small organic molecule |
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| Emp. Form. | C18H19FN2O |
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| Mol. Mass. | 298.3547 |
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| SMILES | COc1cccc(c1)-c1cc(cnc1F)C1CC2CCC1N2 |THB:10:15:18.19:21| |
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| Structure | 
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