| Reaction Details |
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 | Report a problem with these data |
| Target | Delta-type opioid receptor |
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| Ligand | BDBM86959 |
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| Substrate/Competitor | n/a |
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| Ki | 620±n/a nM |
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| Comments | PDSP_8586 |
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| Citation |  Le Bourdonnec, B; Barker, WM; Belanger, S; Wiant, DD; Conway-James, NC; Cassel, JA; O'Neill, TJ; Little, PJ; DeHaven, RN; DeHaven-Hudkins, DL; Dolle, RE Novel trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines as mu opioid receptor antagonists with improved opioid receptor selectivity profiles. Bioorg Med Chem Lett18:2006-12 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article |
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| Delta-type opioid receptor |
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| Name: | Delta-type opioid receptor |
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| Synonyms: | D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 40382.98 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor. |
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| Residue: | 372 |
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| Sequence: | MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA
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| BDBM86959 |
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| n/a |
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| Name | BDBM86959 |
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| Synonyms: | (S)-2-(3-((3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)-N-methylpropanamido)-3-phenylpropanoic acid | CAS_44453900 | NSC_44453900 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H34N2O4 |
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| Mol. Mass. | 438.5592 |
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| SMILES | CC1CN(CCC(=O)N(C)C(Cc2ccccc2)C(O)=O)CCC1(C)c1cccc(O)c1 |
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| Structure | 
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