| Reaction Details |
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 | Report a problem with these data |
| Target | Kappa-type opioid receptor |
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| Ligand | BDBM86961 |
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| Substrate/Competitor | n/a |
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| Ki | 160±n/a nM |
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| Comments | PDSP_8574 |
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| Citation |  Le Bourdonnec, B; Barker, WM; Belanger, S; Wiant, DD; Conway-James, NC; Cassel, JA; O'Neill, TJ; Little, PJ; DeHaven, RN; DeHaven-Hudkins, DL; Dolle, RE Novel trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines as mu opioid receptor antagonists with improved opioid receptor selectivity profiles. Bioorg Med Chem Lett18:2006-12 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article |
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| Kappa-type opioid receptor |
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| Name: | Kappa-type opioid receptor |
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| Synonyms: | K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR) |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 42648.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P41145 |
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| Residue: | 380 |
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| Sequence: | MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALG
STSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRV
RNTVQDPAYLRDIDGMNKPV
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| BDBM86961 |
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| n/a |
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| Name | BDBM86961 |
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| Synonyms: | (S)-2-{(S)-2-benzyl-3-[(3R,4R)-4-(3-hydroxy-phenyl)-3,4-dimethyl-piperidin-1-yl]-propionylamino}-3-biphenyl-4-yl-propionic acid | CAS_44453779 | NSC_44453779 |
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| Type | Small organic molecule |
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| Emp. Form. | C38H42N2O4 |
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| Mol. Mass. | 590.7511 |
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| SMILES | CC1CN(CC(Cc2ccccc2)C(=O)NC(Cc2ccc(cc2)-c2ccccc2)C(O)=O)CCC1(C)c1cccc(O)c1 |
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| Structure | 
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