| Reaction Details |
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 | Report a problem with these data |
| Target | Aurora kinase A |
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| Ligand | BDBM87050 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Activity Assay |
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| pH | 7.4±0 |
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| Temperature | 298.15±0 K |
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| IC50 | 35±4.1 nM |
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| Kd | 49±5.2 nM |
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| Citation |  Martin, MP; Zhu, JY; Lawrence, HR; Pireddu, R; Luo, Y; Alam, R; Ozcan, S; Sebti, SM; Lawrence, NJ; Schönbrunn, E A novel mechanism by which small molecule inhibitors induce the DFG flip in Aurora A. ACS Chem Biol7:698-706 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Aurora kinase A |
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| Name: | Aurora kinase A |
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| Synonyms: | AIK | AIRK1 | ARK1 | AURA | AURKA | AURKA_HUMAN | AYK1 | Aurora 2 | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | IAK1 | STK15 | STK6 | Serine/threonine kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | aurora-2 | hARK1 |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 45830.98 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O14965 |
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| Residue: | 403 |
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| Sequence: | MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRVPLQ
AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN
EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR
EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL
ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM
IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI
SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
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| BDBM87050 |
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| n/a |
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| Name | BDBM87050 |
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| Synonyms: | Bisanilinopyrimidine inhibitor, 4 | Bisanilinopyrimidine, 6h | US9249124, 31 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H13F3N4O2 |
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| Mol. Mass. | 374.3166 |
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| SMILES | OC(=O)c1ccc(Nc2nccc(Nc3ccccc3C(F)(F)F)n2)cc1 |
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| Structure | 
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