| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Nuclear receptor coactivator 3 |
|---|
| Ligand | BDBM87583 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Counterscreen for inhibitors of the Steroid Receptor Coactivator 1 (SRC1; NCOA1) |
|---|
| IC50 | 2090±n/a nM |
|---|
| Citation |  PubChem, PC Counterscreen for inhibitors of the Steroid Receptor Coactivator 1 (SRC1; NCOA1): Luminescence-based cell-based high throughput dose response assay to identify inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3) PubChem Bioassay(2012)[AID] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Nuclear receptor coactivator 3 |
|---|
| Name: | Nuclear receptor coactivator 3 |
|---|
| Synonyms: | AIB1 | BHLHE42 | NCOA3 | NCOA3_HUMAN | RAC3 | TRAM1 | nuclear receptor coactivator 3 isoform a |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 155305.29 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9Y6Q9 |
|---|
| Residue: | 1424 |
|---|
| Sequence: | MSGLGENLDPLASDSRKRKLPCDTPGQGLTCSGEKRRREQESKYIEELAELISANLSDID
NFNVKPDKCAILKETVRQIRQIKEQGKTISNDDDVQKADVSSTGQGVIDKDSLGPLLLQA
LDGFLFVVNRDGNIVFVSENVTQYLQYKQEDLVNTSVYNILHEEDRKDFLKNLPKSTVNG
VSWTNETQRQKSHTFNCRMLMKTPHDILEDINASPEMRQRYETMQCFALSQPRAMMEEGE
DLQSCMICVARRITTGERTFPSNPESFITRHDLSGKVVNIDTNSLRSSMRPGFEDIIRRC
IQRFFSLNDGQSWSQKRHYQEAYLNGHAETPVYRFSLADGTIVTAQTKSKLFRNPVTNDR
HGFVSTHFLQREQNGYRPNPNPVGQGIRPPMAGCNSSVGGMSMSPNQGLQMPSSRAYGLA
DPSTTGQMSGARYGGSSNIASLTPGPGMQSPSSYQNNNYGLNMSSPPHGSPGLAPNQQNI
MISPRNRGSPKIASHQFSPVAGVHSPMASSGNTGNHSFSSSSLSALQAISEGVGTSLLST
LSSPGPKLDNSPNMNITQPSKVSNQDSKSPLGFYCDQNPVESSMCQSNSRDHLSDKESKE
SSVEGAENQRGPLESKGHKKLLQLLTCSSDDRGHSSLTNSPLDSSCKESSVSVTSPSGVS
SSTSGGVSSTSNMHGSLLQEKHRILHKLLQNGNSPAEVAKITAEATGKDTSSITSCGDGN
VVKQEQLSPKKKENNALLRYLLDRDDPSDALSKELQPQVEGVDNKMSQCTSSTIPSSSQE
KDPKIKTETSEEGSGDLDNLDAILGDLTSSDFYNNSISSNGSHLGTKQQVFQGTNSLGLK
SSQSVQSIRPPYNRAVSLDSPVSVGSSPPVKNISAFPMLPKQPMLGGNPRMMDSQENYGS
SMGGPNRNVTVTQTPSSGDWGLPNSKAGRMEPMNSNSMGRPGGDYNTSLPRPALGGSIPT
LPLRSNSIPGARPVLQQQQQMLQMRPGEIPMGMGANPYGQAAASNQLGSWPDGMLSMEQV
SHGTQNRPLLRNSLDDLVGPPSNLEGQSDERALLDQLHTLLSNTDATGLEEIDRALGIPE
LVNQGQALEPKQDAFQGQEAAVMMDQKAGLYGQTYPAQGPPMQGGFHLQGQSPSFNSMMN
QMNQQGNFPLQGMHPRANIMRPRTNTPKQLRMQLQQRLQGQQFLNQSRQALELKMENPTA
GGAAVMRPMMQPQVSSQQGFLNAQMVAQRSRELLSHHFRQQRVAMMMQQQQQQQQQQQQQ
QQQQQQQQQQQQQQQQTQAFSPPPNVTASPSMDGLLAGPTMPQAPPQQFPYQPNYGMGQQ
PDPAFGRVSSPPNAMMSSRMGPSQNPMMQHPQAASIYQSSEMKGWPSGNLARNSSFSQQQ
FAHQGNPAVYSMVHMNGSSGHMGQMNMNPMPMSGMPMGPDQKYC
|
|
|
|---|
| BDBM87583 |
|---|
| n/a |
|---|
| Name | BDBM87583 |
|---|
| Synonyms: | 1-N-(6-bromoquinazolin-4-yl)-4-N,4-N-dimethylbenzene-1,4-diamine | MLS001203424 | N-(6-Bromo-quinazolin-4-yl)-N',N'-dimethyl-benzene-1,4-diamine | N1-(6-bromanylquinazolin-4-yl)-N4,N4-dimethyl-benzene-1,4-diamine | N1-(6-bromo-4-quinazolinyl)-N4,N4-dimethylbenzene-1,4-diamine | SMR000518847 | [4-[(6-bromoquinazolin-4-yl)amino]phenyl]-dimethyl-amine | cid_702724 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H15BrN4 |
|---|
| Mol. Mass. | 343.221 |
|---|
| SMILES | CN(C)c1ccc(Nc2ncnc3ccc(Br)cc23)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
