Ki Summary

Reaction Details

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Target

26S proteasome non-ATPase regulatory subunit 14

Ligand

BDBM46246

Substrate/Competitor

n/a

Meas. Tech.

Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay

IC50

5260±752 nM

Citation

PubChem, PC Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay PubChem Bioassay(2012)[AID]

More Info.:

Get all data from this article, Assay Method

26S proteasome non-ATPase regulatory subunit 14

Name:

26S proteasome non-ATPase regulatory subunit 14

Synonyms:

26S Proteasome regulatory subunit Rpn11 (Rpn11) | POH1 | PSDE_HUMAN | PSMD14 | PSMD14 protein

Type:

Protein

Mol. Mass.:

34576.68

Organism:

Homo sapiens (Human)

Description:

O00487

Residue:

310

Sequence:

MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGE
FVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGC
WLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSN
LGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKH
NESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCL
AAMLDTVVFK

BDBM46246

n/a

Name

BDBM46246

Synonyms:

4-[(5Z)-5-[[5-(1,3-benzothiazol-2-yl)-2-furanyl]methylidene]-4-oxo-2-sulfanylidene-3-thiazolidinyl]butanoic acid | 4-[(5Z)-5-[[5-(1,3-benzothiazol-2-yl)-2-furyl]methylene]-4-keto-2-thioxo-thiazolidin-3-yl]butyric acid | 4-[(5Z)-5-[[5-(1,3-benzothiazol-2-yl)furan-2-yl]methylidene]-4-oxidanylidene-2-sulfanylidene-1,3-thiazolidin-3-yl]butanoic acid | 4-[(5Z)-5-[[5-(1,3-benzothiazol-2-yl)furan-2-yl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanoic acid | MLS-0109411.0001 | US20230364057, Compound 41 | cid_2012947

Type

Small organic molecule

Emp. Form.

C19H14N2O4S3

Mol. Mass.

430.52

SMILES

OC(=O)CCCN1C(=S)S\C(=C/c2ccc(o2)-c2nc3ccccc3s2)C1=O

Structure