Ki Summary

Reaction Details

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Target

26S proteasome non-ATPase regulatory subunit 14

Ligand

BDBM88845

Substrate/Competitor

n/a

Meas. Tech.

Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay

IC50

3790±163 nM

Citation

PubChem, PC Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay PubChem Bioassay(2012)[AID]

More Info.:

Get all data from this article, Assay Method

26S proteasome non-ATPase regulatory subunit 14

Name:

26S proteasome non-ATPase regulatory subunit 14

Synonyms:

26S Proteasome regulatory subunit Rpn11 (Rpn11) | POH1 | PSDE_HUMAN | PSMD14 | PSMD14 protein

Type:

Protein

Mol. Mass.:

34576.68

Organism:

Homo sapiens (Human)

Description:

O00487

Residue:

310

Sequence:

MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGE
FVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGC
WLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSN
LGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKH
NESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCL
AAMLDTVVFK

BDBM88845

n/a

Name

BDBM88845

Synonyms:

MLS000558818 | N-(1,3-benzothiazol-2-yl)-2-[(5-tert-butyl-[1,2,4]triazolo[4,3-c]quinazolin-3-yl)sulfanyl]acetamide | N-(1,3-benzothiazol-2-yl)-2-[(5-tert-butyl-[1,2,4]triazolo[4,3-c]quinazolin-3-yl)sulfanyl]ethanamide | N-(1,3-benzothiazol-2-yl)-2-[(5-tert-butyl-[1,2,4]triazolo[4,3-c]quinazolin-3-yl)thio]acetamide | N-Benzothiazol-2-yl-2-(5-tert-butyl-[1,2,4]triazolo[4,3-c]quinazolin-3-ylsulfanyl)-acetamide | SMR000173585 | cid_3227435

Type

Small organic molecule

Emp. Form.

C22H20N6OS2

Mol. Mass.

448.564

SMILES

CC(C)(C)c1nc2ccccc2c2nnc(SCC(=O)Nc3nc4ccccc4s3)n12

Structure